Fabrication of electrospun nanofibrous clinoptilolite doped thermoplastic polyurethane scaffolds for skeletal muscle tissue engineering

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dc.authoridTurkoglu Lacin, Nelisa/0000-0001-9118-5183
dc.authoridSanli, Abdulkadir/0000-0002-9768-9005
dc.authoridAKKURT YILDIRIM, MERYEM/0000-0003-1168-2679
dc.authoridDENKTAS, Cenk/0000-0001-9255-4374
dc.contributor.authorYildirim, Meryem Akkurt
dc.contributor.authorSanli, Abdulkadir
dc.contributor.authorTurkoglu, Nelisa
dc.contributor.authorDenktas, Cenk
dc.date.accessioned2025-02-20T08:42:25Z
dc.date.available2025-02-20T08:42:25Z
dc.date.issued2023
dc.departmentTürk-Alman Üniversitesien_US
dc.description.abstractThe treatment of skeletal muscle, which lost its function with damage or trauma with autologous muscle tissue transfer, is a very problematic approach. Hence, it is critical to develop materials that are mimicking muscle tissue mechanical behaviors and allowing cell adhesion. Polyurethanes (PUs) are one of the most common polymers in tissue engineering applications and skeletal muscle regeneration due to their elasticity and mechanical flexibility. Clinoptilolite (CLN) is a hydrated alumina silica crystal based biocompatible material that numerous positive effects on animal and human health. Here, we report the synthesize of flexible membranes based on clinoptilolite (CLN) doped thermoplastic polyurethane (TPU) nanofiber network to be used in the field of skeletal muscle regeneration. We primarily evaluated their ability to mimic skeletal muscle by determining their mechanical properties and cell adhesion rates. We observe that cell adhesion and proliferation increased with the increase of CLN contribution. Young modulus (E-Y) values of pure TPU, 5 and 10 wt.% CLN-doped TPU fibers are 3.66, 2.37, and 1.85 MPa, respectively. Mechanical elongations at break of pure TPU, 5 and 10 wt.% CLN-doped TPU fibers after 37 degrees C treatment (7th day) are 193.41%, 113.30%, and 197.15%, respectively. With the addition of 5 wt.% CLN, the thermal stability slightly increased compared to the pure TPU and 10 wt.% CLN/TPU. In addition, cytotoxicity studies reveal that CLN/PU membranes are biocompatible, and finally cell adhesion increases proportionally to the increased CLN contribution. The obtained results indicate that the CLN/PU membranes can be used as a skeletal muscle scaffold.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [121M137]
dc.description.sponsorshipScientific and Technological Research Council of Turkey (Turkiye Bilimsel ve Teknolojik Arastirma Kurumu - TUEBITAK), Grant/Award Number: 121M137
dc.identifier.doi10.1002/app.54233
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue31en_US
dc.identifier.scopus2-s2.0-85160249709
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.54233
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1675
dc.identifier.volume140en_US
dc.identifier.wosWOS:000994529900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250220
dc.subjectclinoptioliteen_US
dc.subjectelectrospun nonofibrousen_US
dc.subjectskeletal muscleen_US
dc.subjectthermoplastic polyurethaneen_US
dc.titleFabrication of electrospun nanofibrous clinoptilolite doped thermoplastic polyurethane scaffolds for skeletal muscle tissue engineering
dc.typeArticle

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