Phytochemical profile and bioactive properties of sage ( <i>Salvia fruticosa</i> ) and thyme ( <i>Thymus vulgaris</i> ) extracts
Yükleniyor...
Tarih
2025-03-19
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Informa UK Limited
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We examined the phytochemical content, antioxidant, antimicrobial, anticholinergic, antidiabetic, and antiglaucoma properties of ethanol and water extracts from Salvia fruticosa (SF) and Thymus vulgaris (TV). Extracts were analyzed using four antioxidant assays, while the enzyme inhibition was tested against alpha-amylase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase II (hCA II). Antimicrobial activity was evaluated against pan-resistant bacterial strains. LC-MS/MS identified rosmarinic acid as the major compound (27.61 and 34.35 mg/L in TV and SF, respectively). Ethanolic extracts had higher phenolic content (181.0 +/- 7.86 and 107.0 +/- 5.78 mu g GAE/mg for SF and TV, respectively). SF showed stronger metal-reducing capacity, while TV had superior radical scavenging ability, judging by the IC50 values (13.68 +/- 1.18 mu g/mL), defined as the concentration that reduces 50% of the enzyme activity. The highest inhibition was observed for hCA II (SF ethanolic extract, IC50 14.51 +/- 4.07 mu g/mL), AChE (SF aqueous extract, IC50 16.51 +/- 3.77 mu g/mL), and BChE (TV aqueous extract, IC50 10.60 +/- 4.93 mu g/mL). SF ethanolic extract inhibited the growth of Staphylococcus aureus and Enterococcus faecalis (11 mm at 60 mu g/mL). These findings highlight SF and TV as potential sources of natural antioxidants, enzyme inhibitors, and antimicrobials for pharmaceutical and food formulations.
Açıklama
Anahtar Kelimeler
Salvia fruticosa, Thymus vulgaris, enzyme inhibition, antioxidant activity, antimicrobial activity
Kaynak
International Journal of Food Properties
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
28
Sayı
1
Künye
Aslan, K., Kopar, E. E., Kelle, K., Karageçili, H., Yilmaz, M. A., Cakir, O., ... & Gulcin, I. (2025). Phytochemical profile and bioactive properties of sage (Salvia fruticosa) and thyme (Thymus vulgaris) extracts. International Journal of Food Properties, 28(1), 2481148.
