Sensitivity of muscle force response of a two-state cross-bridge model to variations in model parameters

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dc.authorid0000-0002-1861-9368
dc.contributor.authorÖrteş, Faruk
dc.contributor.authorJinha, Azim
dc.contributor.authorHerzog, Walter
dc.contributor.authorArslan, Yunus Ziya
dc.date.accessioned2022-11-16T06:57:12Z
dc.date.available2022-11-16T06:57:12Z
dc.date.issued2022
dc.departmentTAÜ, Fen Bilimleri Enstitüsü, Robotlar ve Akıllı Sistemler Ana Bilim Dalı Koleksiyonuen_US
dc.description.abstractMuscle models based on the cross-bridge theory (Huxley-type models) are frequently used to calculate muscle forces for different contractile conditions. Dynamic and nonlinear characteristics of muscle forces produced during isometric, concentric, and eccentric contractions can be represented to a limited extent by using cross-bridge models. Cross-bridge models use various parameters to simulate force responses. However, there remains uncertainty as to the effect of changes in model parameters on force responses in Huxley-type models. In this study, we aimed to analyze the sensitivity of force response to changes in model parameters in Huxley-type models. A two-state Huxley model was used to determine the cross-bridge attachment distributions and forces for shortening and lengthening contractions. Sensitivity of muscle force to changes in attachment rate, detachment rate, and cross-bridge binding distance was examined within a range of +/- 20% of the nominal value using Monte Carlo simulations. Changes in the detachment rate influenced the predicted muscle forces the most for lengthening contractions, while changes in attachment rate and binding distance affected forces the most for shortening contractions. These results show once more the asymmetry between shortening and lengthening contractions and the difficulty in using a single cross-bridge model to predict forces during shortening and elongation accurately.
dc.identifier.citationÖrteş, F., Jinha, A., Herzog, W., Arslan, Yunus Z. (2022). Sensitivity of muscle force response of a two-state cross-bridge model to variations in model parameters. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 236(10), 1513-1520.
dc.identifier.doi10.1177/09544119221122062
dc.identifier.endpage1520en_US
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85138271958
dc.identifier.scopusqualityN/A
dc.identifier.startpage1513en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12846/692
dc.identifier.volume236en_US
dc.identifier.wosWOS:000854306500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorArslan, Yunus Ziya
dc.language.isoen
dc.publisherSage Publications
dc.relation.ispartofProceedings Of The Institution Of Mechanical Engineers Part H-Journal Of Engineerıng In Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCross Bridge Theoryen_US
dc.subjectHuxley Type Modelsen_US
dc.subjectMonte Carlo Simulationen_US
dc.subjectTheorie der Kreuzbrückenen_US
dc.subjectModelle vom Typ Huxleyen_US
dc.subjectMonte Carlo Simulationen_US
dc.subjectÇapraz Köprü Teorisien_US
dc.titleSensitivity of muscle force response of a two-state cross-bridge model to variations in model parameters
dc.typeArticle

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