Slx5/Slx8 SUMO-targeted ubiquitin ligase deficiency shortens lifespan due to increased mutation accumulation in yeast

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dc.authoridTuna, Bilge Guvenc/0000-0003-1348-1336
dc.contributor.authorThomas, Pinar B.
dc.contributor.authorKaluc, Nur
dc.contributor.authorCavli, Irmak N.
dc.contributor.authorTuna, Bilge G.
dc.date.accessioned2025-02-20T08:42:16Z
dc.date.available2025-02-20T08:42:16Z
dc.date.issued2025
dc.departmentTürk-Alman Üniversitesien_US
dc.description.abstractChronological lifespan (CLS) in budding yeast Saccharomyces cerevisiae, which is defined as the time nondividing cells in saturation remain viable, has been utilized as a model to study post-mitotic aging in mammalian cells. CLS is closely related to entry into and maintenance of a quiescent state. Many rearrangements that direct the quiescent state enhance the ability of cells to endure several types of stress. Small ubiquitin-like modifier (SUMO)-targeted ubiquitin ligases (STUbLs) play a critical role in mediating an adaptive response to various stresses. In this study, we investigated the effect of a STUbL, Slx5/Slx8, on CLS in budding yeast. We showed that both SLX5 and SLX8 deletions accelerate chronological aging, resulting in a decreased maximum and mean lifespan. slx5 Delta cells were capable of entering or maintaining a quiescent state during aging. On the other hand, aging slx5 Delta and slx8 Delta cells had both increased spontaneous mutation accumulation. Our data together indicate that Slx5/Slx8 STUbL is required for normal rate of aging by preventing increased spontaneous mutation accumulation during aging. Slx5/Slx8 STUbL deficiency accelerates aging in yeast.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [122Z209, 2209/A-1919B012220692]
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) with the project numbers 122Z209 and 2209/A-1919B012220692.
dc.identifier.doi10.1093/femsle/fnae109
dc.identifier.issn0378-1097
dc.identifier.issn1574-6968
dc.identifier.pmid39730145
dc.identifier.scopus2-s2.0-85215144632
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1093/femsle/fnae109
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1614
dc.identifier.volume372en_US
dc.identifier.wosWOS:001393318500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofFems Microbiology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250220
dc.subjectSlx5/Slx8 STUbL (SUMO-targeted ubiquitin ligase)en_US
dc.subjectchronological agingen_US
dc.subjectquiescenceen_US
dc.subjectmutation accumulationen_US
dc.subjectSaccharomyces cerevisiaeen_US
dc.titleSlx5/Slx8 SUMO-targeted ubiquitin ligase deficiency shortens lifespan due to increased mutation accumulation in yeast
dc.typeArticle

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