Genomic Surveillance and Molecular Characterization of SARS-CoV-2 Variants During the Peak of the Pandemic in Türkiye

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dc.authoridAkcesme, Betul/0000-0002-3730-9963
dc.authoridErkal Cam, Burcin/0000-0002-0275-5613
dc.authoridGezer, Bahar/0000-0002-2054-0034
dc.authoridBAYDILI, Kursad Nuri/0000-0002-2785-0406
dc.authoridIs, Seyma/0000-0002-5151-6758
dc.authoridCag, Yasemin/0000-0002-9983-0308
dc.authoridASLAN, NURAY/0000-0001-8059-4862
dc.contributor.authorAkcesme, Faruk Berat
dc.contributor.authorKoprulu, Tugba Kul
dc.contributor.authorCam, Burcin Erkal
dc.contributor.authorIs, Seyma
dc.contributor.authorKeskin, Birsen Cevher
dc.contributor.authorAkcesme, Betul
dc.contributor.authorBaydili, Kursad Nuri
dc.date.accessioned2025-02-20T08:42:24Z
dc.date.available2025-02-20T08:42:24Z
dc.date.issued2024
dc.departmentTürk-Alman Üniversitesien_US
dc.description.abstractSARS-CoV-2 is a highly transmissible coronavirus and has caused a pandemic of acute respiratory disease. Genomic characterization of SARS-CoV-2 is important for monitoring and assessing its evolution. A total of 1.346 nasopharyngeal swab samples were collected but only 879 SARS-CoV-2 high-quality genomes were isolated, subjected to Next Generation Sequencing and analyzed both statistically and regarding mutations comprehensively. The distribution of clades and lineages in different cities of T & uuml;rkiye and the association of SARS-CoV-2 variants with age groups and clinical characteristics of COVID-19 were also examined. Furthermore, the frequency of the clades and lineages was observed in 10 months. Finally, non-synonymous mutations not defined in specific SARS-CoV-2 variants (during that period) were identified by performing mutation analysis. B.1.1.7 (Alpha) and B.1.617.2 (Delta) SARS-CoV-2 variants which have also been identified in our study from March to December 2021. We observed a significant association of SARS-CoV-2 variants with age groups and cities. Also, E:T9I, S:A27S, S:A67V, S:D796Y, S:K417N, S:N440K, S:R158X, S:S477N (below 1%-frequency) were determined as specific mutations belonging and shared with the Omicron variant that appeared later. Our study has highlighted the importance of constant monitoring of the genetic diversity of SARS-CoV-2 to provide better prevention strategies and it contributes to the understanding of SARS-CoV-2 from the past to the present.
dc.description.sponsorshipUniversity of Health Sciences, Scientific Research Project Unit [2020/130]
dc.description.sponsorshipThis work was supported by the University of Health Sciences, Scientific Research Project Unit [Grant Number: 2020/130].
dc.identifier.doi10.1007/s10528-024-10962-8
dc.identifier.issn0006-2928
dc.identifier.issn1573-4927
dc.identifier.pmid39516327
dc.identifier.scopus2-s2.0-85208956142
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10528-024-10962-8
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1661
dc.identifier.wosWOS:001351171500002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofBiochemical Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250220
dc.subjectSARS-CoV-2en_US
dc.subjectViral genome analysisen_US
dc.subjectVariantsen_US
dc.subjectMutationsen_US
dc.subjectCOVID-19en_US
dc.subjectT & uuml;rkiyeen_US
dc.titleGenomic Surveillance and Molecular Characterization of SARS-CoV-2 Variants During the Peak of the Pandemic in Türkiye
dc.typeArticle

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