Remineralization potential of a novel varnish: an in vitro evaluation

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dc.contributor.authorGokce, Ayse Nur Parlakyildiz
dc.contributor.authorKelesoglu, Ergun
dc.contributor.authorSagir, Kadir
dc.contributor.authorKargul, Betul
dc.date.accessioned2025-02-20T08:42:14Z
dc.date.available2025-02-20T08:42:14Z
dc.date.issued2024
dc.departmentTürk-Alman Üniversitesien_US
dc.description.abstractDespite fluoride's widespread use in preventing dental caries, it remains a significant oral disease with some drawbacks. Consequently, new preventative agents have emerged that can function independently of fluoride. Our aim is to demonstrate the efficacy of newly developed varnishes, 3% Rennou (theobromine calcium and phosphate) and 1% Rennou, in remineralizing initial caries. In our experiment, 40 human enamel samples were randomly allocated into four groups of 10 samples each as: Group 1 (G1): 5% NaF (Colgate PreviDent (R)), Group 2 (G2): 1% Rennou (R), Group 3 (G3): 3% Rennou (R) and Group 4 (G4): Casein Phosphopeptide-Amorphous Calcium Phosphate + Fluoride (MI Varnish (TM) GC). To produce an artificial carious lesion in the enamel, the samples were kept in a demineralizing solution for 72 hours. Samples underwent pH cycling for 6 days in order to induce remineralization. The means of the three measurements were compared, and the percentage of Surface Microhardness Recovery in (SMHR%) was calculated. Scanning Electron Microscopy (SEM) was used for qualitative assessment of surface changes. G1 had the highest SMHR% value, followed by G3, G2 and G4. The One-way ANOVA (Analysis of Variance) showed significant differences in the SMHR% values among the groups after six days of cycling (p < 0.001). In pairwise comparisons, groups did not show differences in means of SMHR% except for G1 and G4 (p = 0.006). In the SEM Images, after treatment within the NaF group, many flaky sediments were found on the enamel surface. Similarly, the maximum mineral gain was seen in the NaF and Rennou groups. SEM images of both varnish surfaces revealed a uniform layer interspersed with shapeless precipitates. All varnishes treated artificial enamel lesions to varying degrees. However, both concentrations of Rennou showed remineralization potential comparable to 5% NaF in acceptable statistical measurements. Thus, it could be used as a potentially effective preventive measure for pediatric patients.
dc.identifier.doi10.22514/jocpd.2024.137
dc.identifier.endpage180en_US
dc.identifier.issn1053-4628
dc.identifier.issn1557-5268
dc.identifier.issue6en_US
dc.identifier.pmid39543894
dc.identifier.scopus2-s2.0-85209173848
dc.identifier.scopusqualityQ3
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.22514/jocpd.2024.137
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1582
dc.identifier.volume48en_US
dc.identifier.wosWOS:001348546400017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMre Press
dc.relation.ispartofJournal of Clinical Pediatric Dentistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250220
dc.subjectTheobromineen_US
dc.subjectRennouen_US
dc.subjectSMHRen_US
dc.subjectVickersen_US
dc.subjectVarnishen_US
dc.subjectRemineralizationen_US
dc.titleRemineralization potential of a novel varnish: an in vitro evaluation
dc.typeArticle

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