Autophagy takes it all-autophagy inducers target immune aging

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dc.authorid0000-0002-0257-4273
dc.contributor.authorZinecker, Heidi
dc.contributor.authorSimon, Anna Katharina
dc.date.accessioned2022-11-04T08:05:02Z
dc.date.available2022-11-04T08:05:02Z
dc.date.issued2022
dc.departmentTAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümüen_US
dc.description.abstractAutophagy, as the key nutrient recycling pathway, enables eukaryotic cells to adapt to surging cellular stress during aging and, thereby, delays age-associated deterioration. Autophagic flux declines with age and, in turn, decreases in autophagy contribute to the aging process itself and promote senescence. Here, we outline how autophagy regulates immune aging and discuss autophagyinducing interventions that target senescent immune cells, which are major drivers of systemic aging. We examine how cutting-edge technologies, such as single-cell omics methods hold the promise to capture the complexity of molecular and cellular phenotypes associated with aging, driving the development of suitable putative biomarkers and clinical bioassays. Finally, we debate the urgency to initiate large-scale human clinical trials. We give special preference to small molecule probes and to dietary interventions that can extend healthy lifespan and are affordable for most of the world's population.
dc.identifier.citationZinecker, H., & Simon, A. K. (2022). Autophagy takes it all–autophagy inducers target immune aging. Disease Models & Mechanisms, 15(1), dmm049345.
dc.identifier.doi10.1242/dmm.049345
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85123905953
dc.identifier.urihttps://hdl.handle.net/20.500.12846/667
dc.identifier.volume15en_US
dc.identifier.wosWOS:000783341300002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorZinecker, Heidi
dc.language.isoen
dc.publisherThe Company of Biologists
dc.relation.ispartofDisease Models & Mechanisms
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAgingen_US
dc.subjectYaşlanmaen_US
dc.subjectAutophagy Induceren_US
dc.subjectImmune Systemen_US
dc.subjectOtofaji İndükleyicisien_US
dc.subjectBağışıklık Sistemien_US
dc.subjectAlternen_US
dc.subjectAutophagie Induktoren_US
dc.subjectImmunsystemen_US
dc.titleAutophagy takes it all-autophagy inducers target immune aging
dc.typeArticle

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