Electrochemical MIP-sensors for drugs

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dc.contributor.authorYarman, Aysu
dc.contributor.authorKurbanoğlu, Sevinç
dc.contributor.authorJetzschmann, Katharina J.
dc.contributor.authorÖzkan, Sibel A.
dc.contributor.authorWollenberger, Ulla
dc.contributor.authorScheller, Frieder W.
dc.date.accessioned2021-01-08T21:51:24Z
dc.date.available2021-01-08T21:51:24Z
dc.date.issued2018
dc.departmentTAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümüen_US
dc.descriptionOzkan, Sibel A./0000-0001-7494-3077; KURBANOGLU, SEVINC/0000-0002-7079-7604en_US
dc.descriptionWOS:000448120700005en_US
dc.descriptionPubMed: 28982312en_US
dc.description.abstractIn order to replace bio-macromolecules by stable synthetic materials in separation techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional monomers are polymerized together with the target analyte and after template removal cavities are formed in the "molecularly imprinted polymer" (MIP) which resemble the active sites of antibodies and enzymes. Starting almost 80 years ago, around 1,100 papers on MIPs were published in 2016. Electropolymerization allows to deposit MIPs directly on voltammetric electrodes or chips for quartz crystal microbalance (QCM) and surface plasmon resonance (SPR). For the readout of MIPs for drugs amperometry, differential pulse voltammetry (DPV) and impedance spectroscopy (EIS) offer higher sensitivity as compared with QCM or SPR. Application of simple electrochemical devices allows both the reproducible preparation of MIP sensors, but also the sensitive signal generation. Electrochemical MIP-sensors for the whole arsenal of drugs, e.g. the most frequently used analgesics, antibiotics and anticancer drugs have been presented in literature and tested under laboratory conditions. These biomimetic sensors typically have measuring ranges covering the lower nano-up to millimolar concentration range and they are stable under extreme pH and in organic solvents like nonaqueous extracts.
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) [UniCat/EXC 314]; ERACHEM [61133]
dc.description.sponsorshipThe authors would like to acknowledge the financial support by the Deutsche Forschungsgemeinschaft (DFG) within the framework of German Excellence Initiative (UniCat/EXC 314) and ERACHEM (2014, 61133).
dc.identifier.doi10.2174/0929867324666171005103712
dc.identifier.endpage4019en_US
dc.identifier.issn0929-8673
dc.identifier.issn1875-533X
dc.identifier.issue33en_US
dc.identifier.scopus2-s2.0-85055657972
dc.identifier.scopusqualityQ1
dc.identifier.startpage4007en_US
dc.identifier.urihttp://doi.org/10.2174/0929867324666171005103712
dc.identifier.urihttps://hdl.handle.net/20.500.12846/231
dc.identifier.volume25en_US
dc.identifier.wosWOS:000448120700005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYarman, Aysu
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Medicinal Chemistry
dc.relation.publicationcategoryother
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiomimetic Sensorsen_US
dc.subjectMolecularly Imprinted Polymersen_US
dc.subjectDrug Sensorsen_US
dc.subjectDrug Imprintingen_US
dc.subjectElectropolymerizationen_US
dc.subjectElectrochemical Sensorsen_US
dc.titleElectrochemical MIP-sensors for drugs
dc.typeReview Article

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