Fabrication and characterization of innovative chitosan/doxorubicin coated 3D printed microneedle patch for prolonged drug delivery

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dc.authoridCamci, Yagmur/0000-0002-0344-4227
dc.authoridTurk, Serbulent/0000-0003-4284-5397
dc.authoridIyibilgin, Osman/0000-0002-1288-1920
dc.authoridOZSOY, Mehmet Iskender/0000-0001-6777-4818
dc.authoridGEPEK, Engin/0000-0001-7340-8363
dc.contributor.authorCamci, Yagmur
dc.contributor.authorTurk, Serbulent
dc.contributor.authorGepek, Engin
dc.contributor.authorIyibilgin, Osman
dc.contributor.authorOzsoy, Mehmet Iskender
dc.date.accessioned2025-02-20T08:42:25Z
dc.date.available2025-02-20T08:42:25Z
dc.date.issued2022
dc.departmentTürk-Alman Üniversitesien_US
dc.description.abstractIn this study, microneedles (MNs) were successfully fabricated using the 3D printing method, which provides ease of production and reproduction in the desired size. Chi/Dox MNs drug delivery systems containing doxorubicin (Dox) were successfully produced in the presence of glutaraldehyde, which was coated with chitosan (Chi) and used as a crosslinker to prolong the drug release of the produced MNs. The obtained Chi/Dox MNs drug distribution systems were characterized by SEM, FTIR, zeta, contact angle, surface energy, compression test, and drug release tests. With the SEM analyzes performed before and after coating, it was observed that the MNs were in micro dimensions, and the diameters of the MNs tips before and after coating were 41.22 mu m and 54.58 mu m, respectively. After the compression test, it was analyzed that each MNs could withstand a force of about 76 N. The zeta potentials of Chi and Dox solutions were measured as 8.8 and 21.5 mV, respectively. FTIR, zeta potential, contact angle, and surface energy results confirm the Dox coating and their interactions. It has been observed that Chi/Dox MNs has successfully extended drug release time without drug-burst, and their use in skin cancer treatment is promising.
dc.description.sponsorshipScientific Research Projects Commission of Sakarya University [2019-6-23-223]
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Commission of Sakarya University (Project number: 2019-6-23-223).
dc.identifier.doi10.1002/app.52759
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue32en_US
dc.identifier.scopus2-s2.0-85132196088
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.52759
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1676
dc.identifier.volume139en_US
dc.identifier.wosWOS:000813646700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250220
dc.subjectbiomaterialsen_US
dc.subjectcrosslinkingen_US
dc.subjectdrug delivery systemsen_US
dc.subjecthydrophilic polymersen_US
dc.subjectnanostructured polymersen_US
dc.titleFabrication and characterization of innovative chitosan/doxorubicin coated 3D printed microneedle patch for prolonged drug delivery
dc.typeArticle

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