Multifunctional alginate-based hydrogel with reversible crosslinking for controlled therapeutics delivery

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dc.contributor.authorBatool, Syeda Rubab
dc.contributor.authorNazeer, Muhammad Anwaar
dc.contributor.authorEkinci, Duygu
dc.contributor.authorŞahin, Afsun
dc.contributor.authorKızılel, Seda
dc.date.accessioned2021-01-08T21:51:20Z
dc.date.available2021-01-08T21:51:20Z
dc.date.issued2020
dc.departmentTAÜ, Fen Fakültesi, Malzeme Bilimi ve Teknolojileri Bölümüen_US
dc.descriptionBatool, Syeda Rubab/0000-0003-1868-0027; Nazeer, Muhammad Anwaar/0000-0002-7906-8010en_US
dc.descriptionWOS:000525869500032en_US
dc.descriptionPubMed: 32035960en_US
dc.description.abstractGlycan-based alginate hydrogels have great potential in creating new vehicles with responsive behavior and tunable properties for biomedicine. However, precise control and tunability in properties present major barrier for clinical translation of these materials. Here, we report the synthesis of pH responsive anthracene modified glycan-based hydrogels for selective release of therapeutic molecules. Hydrogels were crosslinked through simultaneous photopolymerization of vinyl groups and photodimerization of anthracene. Incorporation of anthracene into these gels leads to reversible control on crosslinking and transition between gel/sol states through dimerization/dedimerization of anthracene groups. Chemotherapeutic drug doxorubicin-loaded hydrogels were then tested in a cancer mimetic microenvironment where 85% of the drug was released from anthracene-conjugated hydrogels at pH 2 for 6 days. Control on gelation with anthracene incorporation was observed through alterations in modulus, where storage modulus was increased two-fold with anthracene conjugation during photopolymerization and photodimerization. Furthermore, cell survival analysis revealed that anthracene conjugation could selectively compromise cancer cell viability without inducing significant toxicity on healthy fibroblasts. This study combines light-induced control of crosslink density due to anthracene and pH-triggered therapeutics delivery with alginate. The approach would be applicable for systems where multiple control is required with high precision. (c) 2020 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) under International Support Program (COST Action - European Cooperation in Science and Technology)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [CA18132, 119M171]; Koc University Seed Fund; Presidency of Turkey, Presidency of Strategy and Budget
dc.description.sponsorshipThis study is supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under International Support Program (COST Action - European Cooperation in Science and Technology - CA18132, project number: 119M171) and partially by Koc University Seed Fund. The authors gratefully acknowledge the use of facilities of Koc University Research Center for Surface Science (KUYTAM) and Koc University Research Center for Translational Medicine (KUTTAM), funded by the Presidency of Turkey, Presidency of Strategy and Budget. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Presidency of Strategy and Budget.
dc.identifier.doi10.1016/j.ijbiomac.2020.02.042
dc.identifier.endpage325en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.scopus2-s2.0-85079276807
dc.identifier.scopusqualityQ1
dc.identifier.startpage315en_US
dc.identifier.urihttp://doi.org/10.1016/j.ijbiomac.2020.02.042
dc.identifier.urihttps://hdl.handle.net/20.500.12846/147
dc.identifier.volume150en_US
dc.identifier.wosWOS:000525869500032
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEkinci, Duygu
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal Of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnthracene-Functional Hydrogelen_US
dc.subjectPhotodimerizationen_US
dc.subjectPh-Responsive Hydrogelen_US
dc.titleMultifunctional alginate-based hydrogel with reversible crosslinking for controlled therapeutics delivery
dc.typeArticle

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