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Toplam kayıt 14, listelenen: 1-10
BMP-2 and BMP-9 binding specificities with ALK-3 in aqueous solution with dynamics
(Elsevier Science Inc, 2017)
Signal ligands of the transforming growth factor-beta (TGF-beta) superfamily include the bone morphogenetic proteins (BMPs). BMPs bind to type I and type II serine-threonine kinase receptors and trigger the transphosphorylation ...
Alanine scanning effects on the biochemical and viophysical properties of intrinsically disordered proteins: a case study of the histidine to alanine mutations in amyloid-beta(42)
(Amer Chemical Soc, 2019)
Alanine scanning is a tool in molecular biology that is commonly used to evaluate the contribution of a specific amino acid residue to the stability and function of a protein. Additionally, this tool is also used to ...
Tyrosine regulates beta-sheet structure formation in amyloid-beta(42): a new clustering algorithm for disordered proteins
(Amer Chemical Soc, 2017)
Our recent studies show that the single Tyr residue in the sequence of amyloid-beta(42) (A beta(42)) is reactive toward various ligands, including metals and adenosine trisphospate (see: Coskuner, O. J. Biol. Inorg. Chem. ...
Epitope region identification challenges of intrinsically disordered proteins in neurodegenerative diseases: Secondary structure dependence of alpha-synuclein on simulation techniques and force field parameters
(Wiley, 2020)
Due to fast aggregation processes of many disordered proteins in neurodegenerative diseases, it is difficult to study their epitope regions at the monomeric and oligomeric levels. Computer simulations complement experiments ...
Secondary structure dependence of amyloid-beta(1-40) on simulation techniques and force field parameters
(Wiley, 2021)
Our recent studies revealed that none of the selected widely used force field parameters and molecular dynamics simulation techniques yield structural properties for the intrinsically disordered alpha-synuclein that are ...
Current stage and future perspectives for homology modeling, molecular dynamics simulations, machine learning with molecular dynamics, and quantum computing for intrinsically disordered proteins and proteins with intrinsically disordered regions
(2024)
The structural ensembles of intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) cannot be easily characterized using conventional experimental techniques. Computational ...
Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases
(Elsevier BV., 2022)
Many diferent intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, ...
Intrinsically disordered synthetic polymers in biomedical applications
(Polymers, 2023)
In biology and medicine, intrinsically disordered synthetic polymers bio-mimicking intrinsically disordered proteins, which lack stable three-dimensional structures, possess high structural/conformational flexibility. They ...
Paving the way for synthetic intrinsically disordered polymers for soft robotics
(2023)
Nature is full of examples of processes that, through evolution, have been perfected over
the ages to effectively use matter and sustain life. Here, we present our strategies for designing intrinsically disordered smart ...
Structures of MERS-CoV macro domain in aqueous solution with dynamics: Impacts of parallel tempering simulation techniques and\n CHARMM36m\n and\n AMBER99SB\n force field parameters
(Wiley, 2021)
A novel virus, severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), causing
coronavirus disease 2019 (COVID-19) worldwide appeared in 2019. Detailed scientific
knowledge of the members of the Coronaviridae family, ...