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dc.contributor.authorSözener, Neşe Aral
dc.contributor.authorKabakçıoğlu, Alkan
dc.date.accessioned2024-05-10T11:16:21Z
dc.date.available2024-05-10T11:16:21Z
dc.date.issued2016en_US
dc.identifier.citationSözener, Neşe A., Kabakçıoğlu, A. (2016). Coherent organization in gene regulation a study on six networks. Physical Biology, 13 (2).en_US
dc.identifier.urihttps://iopscience.iop.org/article/10.1088/1478-3975/13/2/026006
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1232
dc.description.abstractStructural and dynamical fingerprints of evolutionary optimization in biological networks are still unclear. Here we analyze the dynamics of genetic regulatory networks responsible for the regulation of cell cycle and cell differentiation in three organisms or cell types each, and show that they follow a version of Hebb's rule which we have termed coherence. More precisely, we find that simultaneously expressed genes with a common target are less likely to act antagonistically at the attractors of the regulatory dynamics. We then investigate the dependence of coherence on structural parameters, such as the mean number of inputs per node and the activatory/repressory interaction ratio, as well as on dynamically determined quantities, such as the basin size and the number of expressed genes.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1088/1478-3975/13/2/026006en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleCoherent organization in gene regulation a study on six networksen_US
dc.typearticleen_US
dc.relation.journalPhysical Biologyen_US
dc.contributor.authorID0000-0002-5458-1053en_US
dc.identifier.volume13en_US
dc.identifier.issue2en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.departmentTAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümüen_US


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