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dc.contributor.authorMirzanlı, Ozan
dc.contributor.authorCoşkuner Weber, Orkid
dc.contributor.authorUversky, Vladimir N.
dc.date.accessioned2024-05-07T06:41:09Z
dc.date.available2024-05-07T06:41:09Z
dc.date.issued2022en_US
dc.identifier.citationMirzanlı, O., Coşkuner Weber, O., Uversky, Vladimir N. (2022). Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases. Biophysical Reviews içerisinde 14, 679-707.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1222
dc.description.abstractMany diferent intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, CHCHD10, and G-protein coupled receptors are increasingly becoming evaluated as potential drug targets in the pharmaceutical-based treatment approaches. Here, we focus on the neurobiology of this class of proteins, which lie at the center of numerous neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, Huntington’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Charcot–Marie–Tooth diseases, spinal muscular atrophy, and mitochondrial myopathy. Furthermore, we discuss the current treatment design strategies involving intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases. In addition, we emphasize that although the G-protein coupled receptors are traditionally investigated using structural biology-based models and approaches, current studies show that these receptors are proteins with intrinsically disordered regions and therefore they require new ways for their analysis.en_US
dc.language.isoengen_US
dc.publisherElsevier BV.en_US
dc.relation.isversionof10.1007/s12551-022-00968-0en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntrinsically disordered proteinsen_US
dc.subjectProteins with intrinsically disordered regionsen_US
dc.subjectNeurodegenerationen_US
dc.subjectPathologyen_US
dc.subjectDrug designen_US
dc.titleIntrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseasesen_US
dc.typearticleen_US
dc.relation.journalBiophysical Reviewsen_US
dc.contributor.authorID0000-0002-0772-9350en_US
dc.identifier.volume14en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.departmentTAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümüen_US
dc.identifier.startpage679en_US
dc.identifier.endpage707en_US


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