Başlık için PubMed İndeksli Yayın Koleksiyonu listeleme
Toplam kayıt 48, listelenen: 1-20
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3In-silico prediction of synergistic anti-cancer drug combinations using multi-omics data
(Nature Publishing Group, 2019)Chemotherapy is a routine treatment approach for early-stage cancers, but the effectiveness of such treatments is often limited by drug resistance, toxicity, and tumor heterogeneity. Combination chemotherapy, in which two ... -
Alanine scanning effects on the biochemical and viophysical properties of intrinsically disordered proteins: a case study of the histidine to alanine mutations in amyloid-beta(42)
(Amer Chemical Soc, 2019)Alanine scanning is a tool in molecular biology that is commonly used to evaluate the contribution of a specific amino acid residue to the stability and function of a protein. Additionally, this tool is also used to ... -
BMP-2 and BMP-9 binding specificities with ALK-3 in aqueous solution with dynamics
(Elsevier Science Inc, 2017)Signal ligands of the transforming growth factor-beta (TGF-beta) superfamily include the bone morphogenetic proteins (BMPs). BMPs bind to type I and type II serine-threonine kinase receptors and trigger the transphosphorylation ... -
Calibration-free extraction of constitutive parameters of magnetically coupled anisotropic metamaterials using waveguide measurements
(Amer Inst Physics, 2017)A calibration-free method for extraction of electromagnetic properties of magnetically coupled anisotropic biaxial metamaterial (MM) slabs from waveguide measurements is proposed. It relies on three measurement steps (thru, ... -
Classification of breast cancer histopathological images using DenseNet and transfer learning
(Hindawi Publishing Corporation, 2022)Breast cancer is one of the most common invading cancers in women. Analyzing breast cancer is nontrivial and may lead to disagreements among experts. Although deep learning methods achieved an excellent performance in ... -
Development of a larval zebrafish infection model for clostridioides difficile
(Journal Of Visualized Experiments, 2020)Clostridioides difficile infection (CDI) is considered to be one of the most common healthcare-associated gastrointestinal infections in the United States. The innate immune response against C. difficile has been described, ... -
The effect of preceramic soldering on fracture resistance of 4-unit zirconia fixed dental prostheses
(Wiley, 2022)Purpose Preceramic soldering of zirconia may deliver better fitting restorations. However, there is not sufficient evidence regarding the influence of preceramic soldering of zirconia restorations on mechanical strength. ... -
Electrochemical MIP sensor for butyrylcholinesterase
(Mdpi, 2019)Molecularly imprinted polymers (MIPs) mimic the binding sites of antibodies by substituting the amino acid-scaffold of proteins by synthetic polymers. In this work, the first MIP for the recognition of the diagnostically ... -
Electrochemical MIP-sensors for drugs
(Bentham Science Publ Ltd, 2018)In order to replace bio-macromolecules by stable synthetic materials in separation techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional monomers are polymerized together with the ... -
Electrosynthesized MIPs for transferrin: Plastibodies or nano-filters?
(Elsevier Advanced Technology, 2018)Molecularly imprinted polymer (MP) nanofilrns for transferrin (Trf) have been synthesized on gold surfaces by electro-polymerizing the functional monomer scopoletin in the presence of the protein target or around pre-adsorbed ... -
Epitope region identification challenges of intrinsically disordered proteins in neurodegenerative diseases: Secondary structure dependence of alpha-synuclein on simulation techniques and force field parameters
(Wiley, 2020)Due to fast aggregation processes of many disordered proteins in neurodegenerative diseases, it is difficult to study their epitope regions at the monomeric and oligomeric levels. Computer simulations complement experiments ... -
FKBPs in bacterial infections
(Elsevier Science Bv, 2015)Background: FK506-binding proteins (FKBPs) contain a domain with peptidyl-prolyl-cis/trans-isomerase (PPlase) activity and bind the immunosuppressive drugs FK506 and rapamycin. FKBPs belong to the immunophilin family and ... -
Green supplier evaluation with SWARA-TOPSIS integrated method to reduce ecological risk factors
(Springer, 2019)One of the most important agendas of the world is the topic of global warming. In order to protect the ecological balance, all organizations turning towards using natural resources more effectively and not harming the ... -
Harmony search optimisation of dispersed laminated composite plates
(Mdpi, 2020)One of the major goals in the process of designing structural components is to achieve the highest possible buckling load of the structural component while keeping the cost and weight at a minimum. This paper illustrates ... -
How an ACE2 mimicking epitope-MIP nanofilm recognizes template-related peptides and the receptor binding domain of SARS-CoV-2
(Royal Society of Chemistry, 2022)Here we aim to gain a mechanistic understanding of the formation of epitope-imprinted polymer nanofilms using a non-terminal peptide sequence, i.e. the peptide GFNCYFP (G485 to P491) of the SARS-CoV-2 receptor binding ... -
Insights into the molecular mechanisms of Alzheimer's and Parkinson's diseases with molecular simulations: understanding the roles of artificial and pathological missense mutations in intrinsically disordered proteins related to pathology
(Mdpi, 2018)Amyloid-beta and alpha-synuclein are intrinsically disordered proteins (IDPs), which are at the center of Alzheimer's and Parkinson's disease pathologies, respectively. These IDPs are extremely flexible and do not adopt ... -
Interpretable machine learning algorithms to predict the axial capacity of frp-reinforced concrete columns
(MDPI-Multidisciplinary Digital Publishing Institute, 2022)Fiber-reinforced polymer (FRP) rebars are increasingly being used as an alternative to steel rebars in reinforced concrete (RC) members due to their excellent corrosion resistance capability and enhanced mechanical properties. ... -
Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases
(Elsevier Academic Press Inc, 2019)Amyloid-beta (A beta) and alpha-synuclein (alpha S) are two intrinsically disordered proteins (IDPs) at the centers of the pathogenesis of Alzheimer's and Parkinson's diseases, respectively. Different hypotheses have been ... -
Ion-imprinted polymer-on-a-sensor for copper detection
(MDPI-Multidisciplinary Digital Publishing Institute, 2022)The accumulation of metal ions in the body is caused by human activities and industrial uses. Among these metal ions, copper is the third most abundant ion found in the human body and is indispensable for health because ... -
Matching algorithm for improving ride-sharing by incorporating route splits and social factors
(Public Library Science, 2020)Increasing traffic congestion and the advancements in technology have fostered the growth of alternative transportation modes such as dynamic ride-sharing. Smartphone technologies have enabled dynamic ride-sharing to thrive, ...
