Yazar "TAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümü" için listeleme
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Molekularer abdruck oder selektion bei der erzeugung biomimetischer specifyer
Oktay, Aysel; Menger, Marcus M.; Yarman, Ayşe; Scheller, Frieder W. (Springer, 2023)Zum Ersatz oder auch zur Ergänzung von Antikörpern für niedermolekulare Substanzen wie Antibiotika, Umweltgifte und Pharmaka, aber auch für Proteinbiomarker, Viren und Mikroorganismen in Trennungstechniken, Diagnostik und ... -
NFI transcriptionally represses CDON and is required for SH-SY5Y cell survival
Uluca, Betül; Esen, Cemre Lektemur; Erdoğan, Sinem Sarıtaş; Kumbasar, Aslı (Elsevier, 2022)Nuclear Factor One (NFI) family of transcription factors regulate proliferation and multiple aspects of differentiation, playing analogous roles in embryonic development and various types of cancer. While all NFI family ... -
Novel cycloheximide derivatives targeting the moonlighting protein Mip exhibit specific antimicrobial activity against Legionella pneumophila
Rasch, Janine; Theuerkorn, Martin; Ünal, Can Murat; Heinsohn, Natascha; Tran, Stefan; Fischer, Gunter; Steinert, Michael (Frontiers Media Sa, 2015)Macrophage infectivity potentiator (Mip) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of ... -
Novel therapeutic strategies for Clostridium difficile infections
Ünal, Can Murat; Steinert, Michael (Taylor & Francis Ltd, 2016)Introduction: In recent years, Clostridium difficile has become the primary cause of antibiotic-associated diarrhea and pseudomembranous colitis, resulting in long and complicated hospital stays that represent a serious ... -
“Out of pocket” protein binding—A dilemma of epitope imprinted polymers revealed for human hemoglobin
Zhang, Xiaorong; Caserta, Giorgio; Supala, Eszter; Wollenberger, Ulla; Gyurcsányi, Róbert E.; Zebger, Ingo; Scheller, Frieder W.; Yarman, Aysu (2021)The epitope imprinting approach applies exposed peptides as templates to synthesize Molecularly Imprinted Polymers (MIPs) for the recognition of the parent protein. While generally the template protein binding to such ... -
Paving the way for synthetic intrinsically disordered polymers for soft robotics
Nature is full of examples of processes that, through evolution, have been perfected over the ages to effectively use matter and sustain life. Here, we present our strategies for designing intrinsically disordered smart ... -
Peptide epitope-imprinted polymer microarrays for selective protein recognition. Application for SARSCoV-2 RBD protein
Yarman, Aysu; Bognar, Zso´fia; Supala, Eszter; Zhang, Xiaorong; Bier, Frank F.; Scheller, Frieder W.; Gyurcsanyi, Robert E. (2022)We introduce a practically generic approach for the generation of epitope-imprinted polymer-based microarrays for protein recognition on surface plasmon resonance imaging (SPRi) chips. The SPRi platform allows the ... -
Peptidylprolyl cis-trans isomerases of Legionella pneumophila: virulence, moonlighting and novel therapeutic targets
Rasch, Janine; Ünal, Can Murat; Steinert, Michael (Portland Press Ltd, 2014)Legionella pneumophila, typically a parasite of free-living protozoa, can also replicate in human alveolar macrophages and lung epithelial cells causing Legionnaires' disease in humans, a severe atypical pneumonia. The ... -
The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions
Xiong, Qiuhong; Ünal, Can Murat; Matthias, Jan; Steinert, Michael; Eichinger, Ludwig (Royal Soc, 2015)Macroautophagy is a highly conserved intracellular bulk degradation system of all eukaryotic cells. It is governed by a large number of autophagy proteins (ATGs) and is crucial for many cellular processes. Here, we describe ... -
Pleiotropic clostridioides difficile cyclophilin PpiB controls cysteine-tolerance, toxin production, the central metabolism and multiple stress responses
Ünal, Can Murat; Karagoz, Mustafa Safa; Berges, Mareike; Priebe, Christina; de Acuna, Jose Manuel Borrero; Wissing, Josef; Steinert, Michael (Frontiers Media Sa, 2019)The Gram-positive pathogen Clostridioides difficile is the main bacterial agent of nosocomial antibiotic associated diarrhea. Bacterial peptidyl-prolyl-cis/trans-isomerases (PPlases) are well established modulators of ... -
Polyketide synthase (PKS) reduces fusion of Legionella pneumophila-containing vacuoles with lysosomes and contributes to bacterial competitiveness during infection
Shevchuk, Olga; Paegelow, Dennis; Rasch, Janine; Döhrmann, Simon; Günther, Gabriele; Hoppe, Julia; Steinert, Michael; Ünal, Can Murat; Bronietzki, Marc; Gutierrez, Maximiliano Gabriel (Elsevier Gmbh, Urban & Fischer Verlag, 2014)L. pneumophila-containing vacuoles (LCVs) exclude endocytic and lysosomal markers in human macrophages and protozoa. We screened a L. pneumophila mini-Tn10 transposon library for mutants, which fail to inhibit the fusion ... -
Present state of MIP-based sensors for SARS-CoV-2
Yarman, Aysu; Kurbanoğlu, Sevinç; Scheller, Frieder W. (Elsevier, 2022)[Özet yok] -
PrsA2 (CD630_35000) of clostridioides difficile Is an Active Parvulin-Type PPlase and a virulence modulator
Ünal, Can Murat; Berges, Mareike; Smit, Nathiana; Schiene-Fischer, Cordelia; Priebe, Christina; Strowig, Till; Steinert, Michael (Frontiers Media Sa, 2018)Clostridioides difficile is the main cause for nosocomial antibiotic associated diarrhea and has become a major burden for the health care systems of industrial countries. Its main virulence factors, the small GTPase ... -
Quantum chemistry meets deep learning for complex carbohydrate and glycopeptide species I
Carbohydrate complexes are crucial in many various biological and medicinal processes. The impacts of N-acetyl on the glycosidic linkage flexibility of methyl β-D-glucopyranose, and of the glycoamino acid β-D-glucopyrano ... -
Revisiting cu(II) bound amyloid-?40 and amyloid-?42 peptides: varying coordination chemistries
Weber, Orkide Coşkuner (Turkish Chemical Society, 2018)Metal ions and intrinsically disordered peptides amyloid-?40 and amyloid-?42 are at the center of Alzheimer´s disease pathology. Divalent copper ion binds to amyloid-?40 and amyloid-?42 peptides with varying coordination ... -
Secondary structure dependence of amyloid-beta(1-40) on simulation techniques and force field parameters
Çalışkan, Murat; Mandacı, Sunay Y.; Uversky, Vladimir N.; Weber, Orkide Coşkuner (Wiley, 2021)Our recent studies revealed that none of the selected widely used force field parameters and molecular dynamics simulation techniques yield structural properties for the intrinsically disordered alpha-synuclein that are ... -
Simple and robust: The claims of protein sensing by molecularly imprinted polymers
A spectrum of 7562 publications on Molecularly Imprinted Polymers (MIPs) has been presented in literature within the last ten years (Scopus, September 7, 2020). Around 10 % of the papers published on MIPs describe ... -
Simultaneous determination of hydrochlorothiazide and irbesartan from pharmaceutical dosage forms with RP-HPLC
Yarman, Aysu; Kurbanoğlu, Sevinç (2000)Objectives: In this work, a simple and rapid liquid chromatographic method for the simultaneous determination of irbesartan (IRBE) and hydrochlorothiazide (HCT) was developed and validated by reverse phase high performance ... -
Structures of MERS-CoV macro domain in aqueous solution with dynamics: Impacts of parallel tempering simulation techniques and\n CHARMM36m\n and\n AMBER99SB\n force field parameters
Akbayrak, İbrahim Yağız; Çağlayan, Şule İrem; Durdağı, Serdar; Kurgan, Lukasz; Uversky, Vladimir N.; Ulver, Burak; Dervişoğlu, Havvanur; Haklıdır, Mehmet; Hasekioğlu, Orkun; Coşkuner Weber, Orkid (Wiley, 2021)A novel virus, severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19) worldwide appeared in 2019. Detailed scientific knowledge of the members of the Coronaviridae family, ...