A comprehensive database analysis of post-translational modifications with chemical and functional categories. A throughout PTM study of 2022 databases.

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dc.contributor.authorGül, Nadir
dc.contributor.authorYıldız, Ahmet
dc.date.accessioned2024-12-06T17:54:14Z
dc.date.available2024-12-06T17:54:14Z
dc.date.issued2023
dc.departmentTAÜ, Mühendislik Fakültesi, Bilgisayar Mühendisliği Bölümüen_US
dc.description.abstractOne of the most important mechanisms that directly affect protein diversity and function is post-translational modification, which has grown exponentially and now encompasses a vast quantity of data. In order to better understand the nature of Post Translational modifications, in this study we elaborated those modifications and classified them into different perspectives In order to base our investigations on high-confidence PTM occurrences, we confined our study to post-translational modifications that have been experimentally verified on humans, leaving out any annotated PTMs based solely on computation prediction. Utilizing chemical and functional details from external databases and literature, 170 distinct alterations from the neXtProt database were examined and identified. These modifications had a total occurrence of 187.220. A careful examination of the data at hand led to the identification of 47 types that contained all 170 modifications. It was revealed that every amino acid underwent at least one type of modification, with cysteine serving as the target of the most diverse modifications—28 in all. Another finding was that most modifications function by converting the target amino acid, while small chemical groups are the most frequent functional groups. The purpose of comprehensively classifying post-translational modifications is to provide an approach that may help understand the effects of these modifications on protein function. It's known that the physicochemical nature of these modifications exerts significant effects on function. However, there is a need to further deepen the current classifications.
dc.identifier.citationGül, N., Yıldız, A. (2023). A comprehensive database analysis of post-translational modifications with chemical and functional categories. A throughout PTM study of 2022 databases. Journal of research in pharmacy, 27 (1), 43-51.
dc.identifier.doi10.29228/jrp.286
dc.identifier.endpage51en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85147828137
dc.identifier.startpage43en_US
dc.identifier.trdizinid1177276
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1177276/a-comprehensive-database-analysis-of-post-translational-modifications-with-chemical-and-functional-categories-a-throughout-ptm-study-of-2022-databases
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1463
dc.identifier.volume27en_US
dc.identifier.wosWOS:000992608700004
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.relation.ispartofJournal of research in pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBiyolojien_US
dc.subjectMikrobiyolojien_US
dc.subjectVirolojien_US
dc.subjectHücre biyolojisien_US
dc.titleA comprehensive database analysis of post-translational modifications with chemical and functional categories. A throughout PTM study of 2022 databases.
dc.typeArticle

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