Disordered peptide-based design of intrinsically disordered polymers for biomedical applications

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dc.contributor.authorCoskuner-Weber, Orkid
dc.contributor.authorCayli, Fatma Nilsu
dc.contributor.authorUversky, Vladimir N.
dc.date.accessioned2025-02-20T08:42:16Z
dc.date.available2025-02-20T08:42:16Z
dc.date.issued2025
dc.departmentTürk-Alman Üniversitesien_US
dc.description.abstractIn the fields of biology and medicine, the development of synthetic polymers that emulate the unique conformational characteristics of intrinsically disordered proteins (IDPs) is of significant interest due to their exceptional structural and conformational versatility. The inherent flexibility of IDPs, arising from their absence of stable three-dimensional structures, enhances their capacity for self-organization, thereby rendering them advantageous for diverse biomedical applications. Intrinsically disordered synthetic polymers hold considerable promise in areas such as drug delivery systems, organ transplantation, artificial organ design, and immune system compatibility. However, advancing the synthesis and characterization methodologies for these polymers, which are derived from the properties of IDPs, remains a critical challenge. This article presents our design strategies for creating intrinsically disordered synthetic polymers tailored for biomedical use. These design methodologies are informed by the attributes of intrinsically disordered proteins and incorporate disorder-promoting oligopeptides.
dc.description.sponsorshipTurkish - German University Scientific Research Projects Commission [2024BF05]
dc.description.sponsorshipThis study was supported by the Turkish - German University Scientific Research Projects Commission under the grant no: 2024BF05.
dc.identifier.doi10.1080/1023666X.2025.2458470
dc.identifier.issn1023-666X
dc.identifier.issn1563-5341
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1080/1023666X.2025.2458470
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1622
dc.identifier.wosWOS:001417142300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Polymer Analysis and Characterization
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250220
dc.subjectIDPolsen_US
dc.subjectintrinsically disordered proteinsen_US
dc.subjectbiomedical applicationsen_US
dc.subjectsynthesisen_US
dc.subjectcharacterizationen_US
dc.subjectdisorder-promoting peptidesen_US
dc.titleDisordered peptide-based design of intrinsically disordered polymers for biomedical applications
dc.typeReview

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