Thermoresponsive intrinsically disordered protein polymers

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dc.contributor.authorUversky, Vladimir N.
dc.contributor.authorTripathi, Timir
dc.contributor.authorCoskuner-Weber, Orkid
dc.date.accessioned2025-02-20T08:46:29Z
dc.date.available2025-02-20T08:46:29Z
dc.date.issued2024
dc.departmentTürk-Alman Üniversitesien_US
dc.description.abstractThermoresponsive intrinsically disordered protein polymers (TIDPPs) are a unique class of biopolymers that lack a fixed three-dimensional structure under physiological conditions and exhibit temperature-responsive behavior. These properties are primarily driven by their amino acid composition and sequence, which lead to changes in solubility and phase transitions at a critical temperature known as the lower critical solution temperature (LCST). TIDPPs transition from a soluble state below the LCST to an aggregated state above it, facilitating applications in drug delivery, tissue engineering, and smart biomaterials. The reversible phase behavior allows for precise control over drug release, targeted delivery, and scaffold properties, enhancing therapeutic efficacy and tissue regeneration. TIDPPs can be engineered to achieve specific LCST values, which make them highly versatile for various biomedical and industrial applications. Their biocompatibility and biodegradability further make them suitable for use in clinical settings, minimizing risks of adverse immune reactions. The field continues to explore the potential of TIDPPs with advanced bioengineering techniques for developing next-generation materials with tunable properties responsive to environmental stimuli. © 2025 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/B978-0-443-21809-5.00016-8
dc.identifier.endpage351en_US
dc.identifier.isbn978-044321809-5
dc.identifier.isbn978-044321810-1
dc.identifier.scopus2-s2.0-85213178818
dc.identifier.startpage333en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-443-21809-5.00016-8
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1739
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofThe Three Functional States of Proteins: Structured, Intrinsically Disordered, and Phase Separated
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250220
dc.subjectCollagen-like polypeptideen_US
dc.subjectElastin-like polypeptideen_US
dc.subjectGlutamine-rich polypeptideen_US
dc.subjectIntrinsically disordered proteinen_US
dc.subjectLower critical solution temperatureen_US
dc.subjectPhase separationen_US
dc.subjectResilin-like polypeptideen_US
dc.subjectSilk-elastin-like proteinen_US
dc.subjectThermoresponsive intrinsically disordered protein polymeren_US
dc.titleThermoresponsive intrinsically disordered protein polymers
dc.typeBook Part

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