Corrosion response and biocompatibility of graphene oxide (GO)–serotonin (Ser) coatings on Ti6Al7Nb and Ti29Nb13Ta4.6Zr (TNTZ) alloys fabricated by electrophoretic deposition (EPD

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dc.authorid0000-0002-3729-3551
dc.contributor.authorOktay, Aysel
dc.contributor.authorYılmazer, Hakan
dc.contributor.authorAgata, Przekora
dc.contributor.authorYılmazer, Yasemin
dc.contributor.authorWojcik, Michal
dc.contributor.authorDikici, Burak
dc.contributor.authorÜstündağ, Cem Bülent
dc.date.accessioned2023-10-23T12:42:38Z
dc.date.available2023-10-23T12:42:38Z
dc.date.issued2023
dc.departmentTAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümüen_US
dc.description.abstractIn this study, Ti6Al7Nb and Ti29Nb13Ta4.6Zr (TNTZ) alloys coated with graphene oxide (GO) and serotonin (Ser) by electrophoretic deposition (EPD) technique were evaluated for possible usage as an orthopedic implant in terms of their in-vitro corrosion response, biocompatibility, and wettability. In-vitro corrosion analyses were carried out to determine the electrochemical response of the coatings in Hanks’ solution (named as SBF) at body temperature (37 ?C). Biocompatibility of the coated materials was evaluated by direct contact method using normal mouse calvarial preosteoblast cell line (MC3T3-E1 Subclone 4). To this purpose, cytotoxic effect and cell proliferation rate were evaluated. The wettability test was performed using static contact angle method (sessile drop technique). The results showed that only GO and GO+Ser coatings had a negative effect on the corrosion resistance of TNTZ alloy. However, the Icorr value of the GO+Ser coatings improved almost 2 and 4 times compared to only GO coated Ti6Al7Nb and uncoated Ti6Al7Nb, respectively. GO+Ser coating made the substrates more hydrophilic, making the surface more suitable for protein adsorption and cell adhesion. Obtained results showed that GO+Ser coated Ti6Al7Nb was more favorable to osteoblast survival (106% viability after 24- h incubation), adhesion and proliferation (almost 6 times faster after 3 days of incubation) compared to only GO coated Ti6Al7Nb (87% viability). Confocal microscope analysis confirmed WST-8 cytotoxicity test results and non-cytotoxicity of the modified surfaces. The GO+Ser coated Ti6Al7Nb possesses better biomedical potential than GO coated Ti6Al7Nb.
dc.identifier.citationOktay, Aysel. Yılmazer, Hakan. Agata, Przekora. Yılmazer, Yasemin. Wojcik, Michal. Dikici, Burak. Üstündağ, Cem Bülent (2023). Corrosion response and biocompatibility of graphene oxide (GO)–serotonin (Ser) coatings on Ti6Al7Nb and Ti29Nb13Ta4.6Zr (TNTZ) alloys fabricated by electrophoretic deposition (EPD). Materials Today Communications, 34(105236), 1-11.
dc.identifier.doi10.1016/j.mtcomm.2022.105236
dc.identifier.endpage11en_US
dc.identifier.isbn23524928
dc.identifier.issue105236en_US
dc.identifier.scopus2-s2.0-85145667421
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2352492822020773?ref=pdf_download&fr=RR-2&rr=81aa13e33bbe92d2
dc.identifier.urihttps://hdl.handle.net/20.500.12846/742
dc.identifier.volume34en_US
dc.identifier.wosWOS:000991252300001
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherMaterials Today Communications
dc.relation.ispartofMaterials Today Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGraphene oxideen_US
dc.subjectSerotoninen_US
dc.subjectElectrophoretic depositionen_US
dc.subjectIn-vitro corrosionen_US
dc.subjectCytotoxicityen_US
dc.subjectOsteoblast proliferationen_US
dc.titleCorrosion response and biocompatibility of graphene oxide (GO)–serotonin (Ser) coatings on Ti6Al7Nb and Ti29Nb13Ta4.6Zr (TNTZ) alloys fabricated by electrophoretic deposition (EPD
dc.typeArticle

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