Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases

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dc.authorid0000-0002-0772-9350
dc.contributor.authorMirzanlı, Ozan
dc.contributor.authorCoşkuner Weber, Orkid
dc.contributor.authorUversky, Vladimir N.
dc.date.accessioned2024-05-07T06:41:09Z
dc.date.available2024-05-07T06:41:09Z
dc.date.issued2022
dc.departmentTAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümüen_US
dc.description.abstractMany diferent intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-?, tau, ?-synuclein, CHCHD2, CHCHD10, and G-protein coupled receptors are increasingly becoming evaluated as potential drug targets in the pharmaceutical-based treatment approaches. Here, we focus on the neurobiology of this class of proteins, which lie at the center of numerous neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, Huntington’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Charcot–Marie–Tooth diseases, spinal muscular atrophy, and mitochondrial myopathy. Furthermore, we discuss the current treatment design strategies involving intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases. In addition, we emphasize that although the G-protein coupled receptors are traditionally investigated using structural biology-based models and approaches, current studies show that these receptors are proteins with intrinsically disordered regions and therefore they require new ways for their analysis.
dc.identifier.citationMirzanlı, O., Coşkuner Weber, O., Uversky, Vladimir N. (2022). Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases. Biophysical Reviews içerisinde 14, 679-707.
dc.identifier.doi10.1007/s12551-022-00968-0
dc.identifier.endpage707en_US
dc.identifier.scopus2-s2.0-85131568857
dc.identifier.startpage679en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1222
dc.identifier.volume14en_US
dc.identifier.wosWOS:001053808600009
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier BV.
dc.relation.ispartofBiophysical Reviews
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIntrinsically disordered proteinsen_US
dc.subjectProteins with intrinsically disordered regionsen_US
dc.subjectNeurodegenerationen_US
dc.subjectPathologyen_US
dc.subjectDrug designen_US
dc.titleIntrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases
dc.typeArticle

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