Başlık için Moleküler Biyoteknoloji listeleme
Toplam kayıt 83, listelenen: 17-36
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Covalent dimerization of interleukin-like epithelial-to-mesenchymal transition (EMT) inducer (ILEI) facilitates EMT, invasion, and late aspects of metastasis
(2017)The interleukin-like epithelial-to-mesenchymal transition (EMT) inducer(ILEI)/FAM3C is a member of the highly homologous FAM3 family andis essential for EMT and metastasis formation. It is upregulated in severalcancers, ... -
Current challenges and limitations in the studies of intrinsically disordered proteins in neurodegenerative diseases by computer simulations
(Bentham Science Publishers, 2020)Experiments face challenges in the analysis of intrinsically disordered proteins in solution due to fast conformational changes and enhanced aggregation propensity. Computational studies complement experiments, being widely ... -
Current stage and future perspectives for homology modeling, molecular dynamics simulations, machine learning with molecular dynamics, and quantum computing for intrinsically disordered proteins and proteins with intrinsically disordered regions
(2024)The structural ensembles of intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) cannot be easily characterized using conventional experimental techniques. Computational ... -
Çörek Otu’nun (Nigella sativa) biyolojik ve farmakolojik özellikleri
(Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, 2023)Ranunculaceae familyasının bir üyesi olan Nigella sativa, Güney Avrupa ve Batı Asya’da doğal olarak yetişen ve dünyanın birçok bölgesinde kültive edilen tek yıllık bir bitkidir. Dünya mutfaklarında baharat olarak ... -
Determination of neural fiber connections based on data structure algorithm
(Hindawi Publishing Corporation, 2010)The brain activity during perception or cognition is mostly examined by functional magnetic resonance imaging (fMRI). However, the cause of the detected activity relies on the anatomy. Diffusion tensor magnetic resonance ... -
Development of a larval zebrafish infection model for clostridioides difficile
(Journal Of Visualized Experiments, 2020)Clostridioides difficile infection (CDI) is considered to be one of the most common healthcare-associated gastrointestinal infections in the United States. The innate immune response against C. difficile has been described, ... -
Development of a molecularly imprinted polymer-based electrochemical sensor for tyrosinase
(Scientific & Technical Research Council Turkey-TUBITAK, 2018)For the first time a molecularly imprinted polymer (MIP)-based sensor for tyrosinase is described. This sensor is based on the electropolymerization of scopoletin or o-phenylenediamine in the presence of tyrosinase from ... -
Editorial
(Elsevier BV, 2023)This special issue on biosensors and protein electrochemistry is dedicated to Professor Frieder W. Scheller on occasion of his 80th birthday in August 2022. Frieder Scheller’s contributions to the field of bioelectroc ... -
Effects of the Jokela type of spinal muscular atrophy-relatedG66V mutation on the structural ensemble characteristics ofCHCHD10
(2023)The G66V pathological variant of the coiled-coil-helix-coiled-coil-helix domain-containing protein 10 (CHCHD10), mitochondrial, plays a role in Jokela type spinalmuscular atrophy. The wild-type and G66V mutant-type CHCHD10 ... -
Electrochemical MIP-sensors for drugs
(Bentham Science Publ Ltd, 2018)In order to replace bio-macromolecules by stable synthetic materials in separation techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional monomers are polymerized together with the ... -
Electrosynthesized MIPs for transferrin: Plastibodies or nano-filters?
(Elsevier Advanced Technology, 2018)Molecularly imprinted polymer (MP) nanofilrns for transferrin (Trf) have been synthesized on gold surfaces by electro-polymerizing the functional monomer scopoletin in the presence of the protein target or around pre-adsorbed ... -
Electrosynthesized molecularly imprinted polymer for laccase using the inactivated enzyme as the target
(Wiley-V C H Verlag Gmbh, 2018)The first molecularly imprinted polymer (MIP) for the recognition of the copper-enzyme laccase was successfully prepared by electropolymerizing scopoletin in the presence of alkaline-inactivated enzyme. Laccase-MIP and the ... -
Enzymes as tools in MIP-Sensors
(Mdpi, 2017)Molecularly imprinted polymers (MIPs) have the potential to complement antibodies in bioanalysis, are more stable under harsh conditions, and are potentially cheaper to produce. However, the affinity and especially the ... -
Epitope region identification challenges of intrinsically disordered proteins in neurodegenerative diseases: Secondary structure dependence of alpha-synuclein on simulation techniques and force field parameters
(Wiley, 2020)Due to fast aggregation processes of many disordered proteins in neurodegenerative diseases, it is difficult to study their epitope regions at the monomeric and oligomeric levels. Computer simulations complement experiments ... -
Evaluation of deep transfer learning methodologies on the COVID-19 radiographic chest images
(International Information and Engineering Technology Association, 2023)In 2019, the world had been attacked with a severe situation by the new version of the SARSCOV-2 virus, which is later called COVID-19. One can use artificial intelligence techniques to reduce time consumption and find ... -
Fiziksel performans etkisinde mental aktivitenin elektrofizyolojik bulgularının değerlendirilmesi
(Academic Platform, 2019)Bu çalışmada, zihinsel işyükü paradigmasının yorgunluk ile ilintisine yönelik elektrofizyolojik ölçüm sonuçları iki farklı grup üzerinden incelenmiştir. Ayrık grup olarak, sporcular ve sedanterler ele alınmış olup, bu ... -
FKBPs in bacterial infections
(Elsevier Science Bv, 2015)Background: FK506-binding proteins (FKBPs) contain a domain with peptidyl-prolyl-cis/trans-isomerase (PPlase) activity and bind the immunosuppressive drugs FK506 and rapamycin. FKBPs belong to the immunophilin family and ... -
From quantum mechanics, classical mechanics, and bioinformatics to artificial intelligence studies in neurodegenerative diseases
(Springer, 2022)The amyloid β-protein is an intrinsically disordered protein that has the potential to assemble into myriad structures, including oligomers and fibrils. These structures are neurotoxic and are thought to initiate a cascade ... -
Frontotemporal dementia-related V57E mutation impairs mitochondrial function and alters the structural properties of CHCHD10
(2023)The V57E pathological variant of the mitochondrial coiled-coil-helix–coiled-coil-helix domain-containing protein 10 (CHCHD10) plays a role in frontotemporal dementia. The wild-type and V57E mutant CHCHD10 proteins contain ...