Yazar "TAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümü" için listeleme
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Çörek Otu’nun (Nigella sativa) biyolojik ve farmakolojik özellikleri
İş, Şeyma (Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, 2023)Ranunculaceae familyasının bir üyesi olan Nigella sativa, Güney Avrupa ve Batı Asya’da doğal olarak yetişen ve dünyanın birçok bölgesinde kültive edilen tek yıllık bir bitkidir. Dünya mutfaklarında baharat olarak ... -
Determination of neural fiber connections based on data structure algorithm
Göksel Duru, Dilek; Özkan, Mehmed (Hindawi Publishing Corporation, 2010)The brain activity during perception or cognition is mostly examined by functional magnetic resonance imaging (fMRI). However, the cause of the detected activity relies on the anatomy. Diffusion tensor magnetic resonance ... -
Development of a larval zebrafish infection model for clostridioides difficile
Li, Junkai; Ünal, Can Murat; Namikawa, Kazuhiko; Steinert, Michael; Koester, Reinhard W. (Journal Of Visualized Experiments, 2020)Clostridioides difficile infection (CDI) is considered to be one of the most common healthcare-associated gastrointestinal infections in the United States. The innate immune response against C. difficile has been described, ... -
Development of a molecularly imprinted polymer-based electrochemical sensor for tyrosinase
Yarman, Aysu (Scientific & Technical Research Council Turkey-TUBITAK, 2018)For the first time a molecularly imprinted polymer (MIP)-based sensor for tyrosinase is described. This sensor is based on the electropolymerization of scopoletin or o-phenylenediamine in the presence of tyrosinase from ... -
Editorial
Yarman, Aysu; Lisdat, Fred; Wollenberger, Ulla (Elsevier BV, 2023)This special issue on biosensors and protein electrochemistry is dedicated to Professor Frieder W. Scheller on occasion of his 80th birthday in August 2022. Frieder Scheller’s contributions to the field of bioelectroc ... -
Effects of the Jokela type of spinal muscular atrophy-relatedG66V mutation on the structural ensemble characteristics ofCHCHD10
The G66V pathological variant of the coiled-coil-helix-coiled-coil-helix domain-containing protein 10 (CHCHD10), mitochondrial, plays a role in Jokela type spinalmuscular atrophy. The wild-type and G66V mutant-type CHCHD10 ... -
Electrochemical MIP sensors for environmental analysis
Yarman, Aysu; Kurbanoğlu, Sevinç; Zhang, Xiaorong; Scheller, Frieder W. (Springer, 2023)[Özet yok] -
Electrochemical MIP-sensors for drugs
Yarman, Aysu; Kurbanoğlu, Sevinç; Jetzschmann, Katharina J.; Özkan, Sibel A.; Wollenberger, Ulla; Scheller, Frieder W. (Bentham Science Publ Ltd, 2018)In order to replace bio-macromolecules by stable synthetic materials in separation techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional monomers are polymerized together with the ... -
Electrosynthesized MIPs for transferrin: Plastibodies or nano-filters?
Zhang, Xiaorong; Yarman, Aysu; Erdossy, Julia; Katz, Sagie; Zebger, Ingo; Jetzschmann, Katharina J.; Scheller, Frieder W. (Elsevier Advanced Technology, 2018)Molecularly imprinted polymer (MP) nanofilrns for transferrin (Trf) have been synthesized on gold surfaces by electro-polymerizing the functional monomer scopoletin in the presence of the protein target or around pre-adsorbed ... -
Electrosynthesized molecularly imprinted polymer for laccase using the inactivated enzyme as the target
Yarman, Aysu (Wiley-V C H Verlag Gmbh, 2018)The first molecularly imprinted polymer (MIP) for the recognition of the copper-enzyme laccase was successfully prepared by electropolymerizing scopoletin in the presence of alkaline-inactivated enzyme. Laccase-MIP and the ... -
Enzymes as tools in MIP-Sensors
Yarman, Aysu; Jetzschmann, Katharina J.; Neumann, Bettina; Zhang, Xiaorong; Wollenberger, Ulla; Cordin, Aude; Scheller, Frieder W. (Mdpi, 2017)Molecularly imprinted polymers (MIPs) have the potential to complement antibodies in bioanalysis, are more stable under harsh conditions, and are potentially cheaper to produce. However, the affinity and especially the ... -
Epitope region identification challenges of intrinsically disordered proteins in neurodegenerative diseases: Secondary structure dependence of alpha-synuclein on simulation techniques and force field parameters
Mandacı, Sunay Yağız; Çalışkan, Murat; Sarıaslan, M. Furkan; Uversky, Vladimir N.; Weber, Orkide Coşkuner (Wiley, 2020)Due to fast aggregation processes of many disordered proteins in neurodegenerative diseases, it is difficult to study their epitope regions at the monomeric and oligomeric levels. Computer simulations complement experiments ... -
Evaluation of deep transfer learning methodologies on the COVID-19 radiographic chest images
Duru, Dilek Göksel; Duru, Adil Deniz; Uçan, Osman Nuri; Al-azzaw, Athar; Al-jumaili, Saif (International Information and Engineering Technology Association, 2023)In 2019, the world had been attacked with a severe situation by the new version of the SARSCOV-2 virus, which is later called COVID-19. One can use artificial intelligence techniques to reduce time consumption and find ... -
Fiziksel performans etkisinde mental aktivitenin elektrofizyolojik bulgularının değerlendirilmesi
Göksel Duru, Dilek; Işıkçı Koca, Elif (Academic Platform, 2019)Bu çalışmada, zihinsel işyükü paradigmasının yorgunluk ile ilintisine yönelik elektrofizyolojik ölçüm sonuçları iki farklı grup üzerinden incelenmiştir. Ayrık grup olarak, sporcular ve sedanterler ele alınmış olup, bu ... -
FKBPs in bacterial infections
Ünal, Can Murat; Steinert, Michael (Elsevier Science Bv, 2015)Background: FK506-binding proteins (FKBPs) contain a domain with peptidyl-prolyl-cis/trans-isomerase (PPlase) activity and bind the immunosuppressive drugs FK506 and rapamycin. FKBPs belong to the immunophilin family and ... -
From quantum mechanics, classical mechanics, and bioinformatics to artificial intelligence studies in neurodegenerative diseases
Habiboğlu, Mehmet Gökhan; Coşkuner Weber, Orkid; Uversky, Vladimir N.; Teplow, David (Springer, 2022)The amyloid β-protein is an intrinsically disordered protein that has the potential to assemble into myriad structures, including oligomers and fibrils. These structures are neurotoxic and are thought to initiate a cascade ... -
Frontotemporal dementia-related V57E mutation impairs mitochondrial function and alters the structural properties of CHCHD10
Alıcı, Hakan; Uversky, Vladimir N.; Liu, Tian; Kang, David E.; Woo, Junga Alexa; Coşkuner Weber, Orkid (2023)The V57E pathological variant of the mitochondrial coiled-coil-helix–coiled-coil-helix domain-containing protein 10 (CHCHD10) plays a role in frontotemporal dementia. The wild-type and V57E mutant CHCHD10 proteins contain ... -
Generating simulated DT-MRI dataset
Göksel Duru, Dilek; Özkan, Mehmed (IGI Global, 2008)Diffusion tensor magnetic resonance imaging (DTMRI), also known as diffusion tensor imaging (DTI), needs post processing by adequate image analysis and visualization tools. White matter tractography using DTI is becoming ... -
Göz hareketlerine dayalı beyin bilgisayar arayüzü tasarımı
Koç, Engin; Bayat, Oğuz; Göksel Duru, Dilek; Duru, Adil Deniz (Kırıkkale Üniversitesi, 2020)Modern teknoloji ile birlikte insanların göz hareketlerini inceleyerek uyaranlara karşı vermiş oldukları tepkiler takip edilebilir hale gelmiştir. Bu takip yöntemlerden biri de Göz İzleme (Eye-Tracking) tekniğidir. Bu ... -
Gözbebeği hareketleri temelli duygu durumu sınıflandırılması
Mete, Samet; Çakır, Oğuz; Bayat, Oğuz; Göksel Duru, Dilek; Duru, Adil Deniz (Gazi Üniversitesi, 2020)İnsanlardaki duygu durumu otonom sinir sistemi tarafından kontrol edilmektedir. Bu sebeple, olumlu veya olumsuz bir uyaran ile karşılaştığında otonom sinir sistemi çok kısa bir süre içerisinde, uyaran çeşidinin bireyde ...