Yazar "Steinert, Michael" için listeleme
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Development of a larval zebrafish infection model for clostridioides difficile
Li, Junkai; Ünal, Can Murat; Namikawa, Kazuhiko; Steinert, Michael; Koester, Reinhard W. (Journal Of Visualized Experiments, 2020)Clostridioides difficile infection (CDI) is considered to be one of the most common healthcare-associated gastrointestinal infections in the United States. The innate immune response against C. difficile has been described, ... -
FKBPs in bacterial infections
Ünal, Can Murat; Steinert, Michael (Elsevier Science Bv, 2015)Background: FK506-binding proteins (FKBPs) contain a domain with peptidyl-prolyl-cis/trans-isomerase (PPlase) activity and bind the immunosuppressive drugs FK506 and rapamycin. FKBPs belong to the immunophilin family and ... -
Microbial peptidyl-prolyl cis/trans isomerases (ppIases): virulence factors and potential alternative drug targets
Ünal, Can Murat; Steinert, Michael (Amer Soc Microbiology, 2014)Initially discovered in the context of immunomodulation, peptidyl-prolyl cis/trans isomerases (PPIases) were soon identified as enzymes catalyzing the rate-limiting protein folding step at peptidyl bonds preceding proline ... -
Novel cycloheximide derivatives targeting the moonlighting protein Mip exhibit specific antimicrobial activity against Legionella pneumophila
Rasch, Janine; Theuerkorn, Martin; Ünal, Can Murat; Heinsohn, Natascha; Tran, Stefan; Fischer, Gunter; Steinert, Michael (Frontiers Media Sa, 2015)Macrophage infectivity potentiator (Mip) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of ... -
Novel therapeutic strategies for Clostridium difficile infections
Ünal, Can Murat; Steinert, Michael (Taylor & Francis Ltd, 2016)Introduction: In recent years, Clostridium difficile has become the primary cause of antibiotic-associated diarrhea and pseudomembranous colitis, resulting in long and complicated hospital stays that represent a serious ... -
Peptidylprolyl cis-trans isomerases of Legionella pneumophila: virulence, moonlighting and novel therapeutic targets
Rasch, Janine; Ünal, Can Murat; Steinert, Michael (Portland Press Ltd, 2014)Legionella pneumophila, typically a parasite of free-living protozoa, can also replicate in human alveolar macrophages and lung epithelial cells causing Legionnaires' disease in humans, a severe atypical pneumonia. The ... -
The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions
Xiong, Qiuhong; Ünal, Can Murat; Matthias, Jan; Steinert, Michael; Eichinger, Ludwig (Royal Soc, 2015)Macroautophagy is a highly conserved intracellular bulk degradation system of all eukaryotic cells. It is governed by a large number of autophagy proteins (ATGs) and is crucial for many cellular processes. Here, we describe ... -
Pleiotropic clostridioides difficile cyclophilin PpiB controls cysteine-tolerance, toxin production, the central metabolism and multiple stress responses
Ünal, Can Murat; Karagoz, Mustafa Safa; Berges, Mareike; Priebe, Christina; de Acuna, Jose Manuel Borrero; Wissing, Josef; Steinert, Michael (Frontiers Media Sa, 2019)The Gram-positive pathogen Clostridioides difficile is the main bacterial agent of nosocomial antibiotic associated diarrhea. Bacterial peptidyl-prolyl-cis/trans-isomerases (PPlases) are well established modulators of ... -
Polyketide synthase (PKS) reduces fusion of Legionella pneumophila-containing vacuoles with lysosomes and contributes to bacterial competitiveness during infection
Shevchuk, Olga; Paegelow, Dennis; Rasch, Janine; Döhrmann, Simon; Günther, Gabriele; Hoppe, Julia; Steinert, Michael; Ünal, Can Murat; Bronietzki, Marc; Gutierrez, Maximiliano Gabriel (Elsevier Gmbh, Urban & Fischer Verlag, 2014)L. pneumophila-containing vacuoles (LCVs) exclude endocytic and lysosomal markers in human macrophages and protozoa. We screened a L. pneumophila mini-Tn10 transposon library for mutants, which fail to inhibit the fusion ... -
PrsA2 (CD630_35000) of clostridioides difficile Is an Active Parvulin-Type PPlase and a virulence modulator
Ünal, Can Murat; Berges, Mareike; Smit, Nathiana; Schiene-Fischer, Cordelia; Priebe, Christina; Strowig, Till; Steinert, Michael (Frontiers Media Sa, 2018)Clostridioides difficile is the main cause for nosocomial antibiotic associated diarrhea and has become a major burden for the health care systems of industrial countries. Its main virulence factors, the small GTPase ... -
Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation
Scheithauer, Lina; Thiem, Stefanie; Schmelz, Stefan; Dellmann, Ansgar; Buessow, Konrad; Brouwer, Rene M. H. J.; Ünal, Can Murat; Blankenfeldt, Wulf; Steinert, Michael (Wiley, 2021)ProA is a secreted zinc metalloprotease of Legionella pneumophila causing lung damage in animal models of Legionnaires' disease. Here we demonstrate that ProA promotes infection of human lung tissue explants (HLTEs) and ...
