A Sensitive Epinephrine Sensor Based on Photochemically Synthesized Gold Nanoparticles

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dc.contributor.authorMetin, Eyüp
dc.contributor.authorBatibay, Gonul S.
dc.contributor.authorAydın, Meral
dc.contributor.authorArsu, Nergis
dc.date.accessioned2025-11-11T05:46:33Z
dc.date.available2025-11-11T05:46:33Z
dc.date.issued2025
dc.departmentTAÜ, Fen Fakültesi, Malzeme Bilimi ve Teknolojileri Bölümü
dc.description.abstractIn this study, gold nanoparticles (AuNPs) and AuNPs-graphene oxide (AuNPs@GO) nanostructures were synthesized in aqueous media using an in-situ photochemical method with bis-acyl phosphine oxide (BAPO) photoinitiator as a photoreducing agent in the presence of HAuCl4. The parameters for synthesis were arranged to obtain stable and reproducible dispersions with desirable chemical and optical properties. Both AuNPs and AuNPs@GO were employed as sensing platforms for the detection of epinephrine in two concentration ranges: micromolar (µM) and nanomolar (nM). Field emission scanning electron microscopy (FE-SEM), Dynamic Light Scattering (DLS), UV-Vis absorption, fluorescence emission, and Fourier Transform Infrared (FT-IR) spectroscopy techniques were used to investigate the morphological, optical, and chemical properties of the nanostructures as well as their sensing ability towards epinephrine. Fluorescence spectroscopy played a crucial role in demonstrating the high sensitivity and effectiveness of these systems, especially in the low concentration (nM) range, confirming their strong potential as fluorescence-based sensors. By constructing calibration curves on best linear subranges, limit of detection (LOD) and limit of quantification (LOQ) were calculated with two different approaches, SEintercept and Sy/x. Among all the investigated nanostructures, AuNPs@GO exhibited the highest sensitivity towards epinephrine. The efficiency and reproducibility of the in-situ photochemical AuNPs synthesis approach highlight its applicability in small-molecule detection and particularly in analytical and bio-sensing applications.
dc.identifier.citationMetin, E., Batibay, Gonul S., Aydın, M., Arsu, N. (2025). A Sensitive Epinephrine Sensor Based on Photochemically Synthesized Gold Nanoparticles. Chemosensors, 13 (7), 229, 1-21.
dc.identifier.doi10.3390/chemosensors13070229
dc.identifier.endpage21
dc.identifier.issue7
dc.identifier.startpage1
dc.identifier.urihttps://www.mdpi.com/2227-9040/13/7/229
dc.identifier.urihttps://hdl.handle.net/20.500.12846/2084
dc.identifier.volume13
dc.language.isoen
dc.relation.ispartofChemosensors
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectphotochemical synthesis
dc.subjectgold nanoparticles
dc.subjectepinephrine detection
dc.subjectsmall molecule detection
dc.subjectLOD
dc.subjectLOQ
dc.titleA Sensitive Epinephrine Sensor Based on Photochemically Synthesized Gold Nanoparticles
dc.typeArticle

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