Design criteria for a high energy Compton Camera and possible application to targeted cancer therapy
Yükleniyor...
Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Iop Publishing Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The proposed research focuses on the design criteria for a Compton Camera with high spatial resolution and sensitivity, operating at high gamma energies and its possible application for molecular imaging. This application is mainly on the detection and visualization of the pharmacokinetics of tumor targeting substances specific for particular cancer sites. Expected high resolution (< 0.5 mm) permits monitoring the pharmacokinetics of labeled gene constructs in vivo in small animals with a human tumor xenograft which is one of the first steps in evaluating the potential utility of a candidate gene. The additional benefit of high sensitivity detection will be improved cancer treatment strategies in patients based on the use of specific molecules binding to cancer sites for early detection of tumors and identifying metastasis, monitoring drug delivery and radionuclide therapy for optimum cell killing at the tumor site. This new technology can provide high resolution, high sensitivity imaging of a wide range of gamma energies and will significantly extend the range of radiotracers that can be investigated and used clinically. The small and compact construction of the proposed camera system allows flexible application which will be particularly useful for monitoring residual tumor around the resection site during surgery. It is also envisaged as able to test the performance of new drug/gene-based therapies in vitro and in vivo for tumor targeting efficacy using automatic large scale screening methods.
Açıklama
16th International Workshop on Radiation Imaging Detectors, JUN 22-26, 2014, Trieste, ITALY
Conka, Tuba/0000-0003-0671-3805
WOS:000362265600018
Conka, Tuba/0000-0003-0671-3805
WOS:000362265600018
Anahtar Kelimeler
Compton Imaging, Instrumentation For Gamma-Electron Therapy, Detector Modelling And Simulations I (Interaction Of Radiation With Matter, Interaction Of Photons With Matter, Interaction Of Hadrons With Matter, Etc), Gamma Detectors (Scintillators, Czt, Hpg, Hgi Etc)
Kaynak
Journal Of Instrumentation
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
10
