Liquid-Liquid Phase Separation Associated with Intrinsically Disordered Proteins: Experimental and Computational Tools

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dc.contributor.authorUversky, Vladimir N.
dc.contributor.authorCoşkuner Weber, Orkid
dc.date.accessioned2024-10-02T19:39:17Z
dc.date.available2024-10-02T19:39:17Z
dc.date.issued2024
dc.departmentTAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümüen_US
dc.description.abstractThe phenomenon of Liquid-Liquid Phase Separation (LLPS) serves as a vital mechanism for the spatial organization of biomolecules, significantly influencing the elementary processes within the cellular milieu. Intrinsically disordered proteins, or proteins endowed with intrinsically disordered regions, are pivotal in driving this biophysical process, thereby dictating the formation of non-membranous cellular compartments. Compelling evidence has linked aberrations in LLPS to the pathogenesis of various neurodegenerative diseases, underscored by the disordered proteins’ proclivity to form pathological aggregates. This study meticulously evaluates the arsenal of contemporary experimental and computational methodologies dedicated to the examination of intrinsically disordered proteins within the context of LLPS. Through a discerning discourse on the capabilities and constraints of these investigative techniques, we unravel the intricate contributions of these ubiquitous proteins to LLPS and neurodegeneration. Moreover, we project a future trajectory for the field, contemplating on innovative research tools and their potential to elucidate the underlying mechanisms of LLPS, with the ultimate goal of fostering new therapeutic avenues for combating neurodegenerative disorders.
dc.identifier.citationUversky, Vladimir N., Coşkuner Weber, O. (2024). Liquid-Liquid Phase Separation Associated with Intrinsically Disordered Proteins: Experimental and Computational Tools. Current Protein & Peptide Science, 25.
dc.identifier.doi10.2174/0113892037314062240618193044
dc.identifier.issn1389-2037
dc.identifier.urihttps://www.eurekaselect.com/article/141534
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1378
dc.identifier.volume25en_US
dc.language.isoen
dc.relation.ispartofCurrent Protein & Peptide Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectLiquid-liquid phase separationen_US
dc.subjectIntrinsically disordered proteinsen_US
dc.subjectProteins with intrinsically disordered regionsen_US
dc.subjectExperimental toolsen_US
dc.subjectComputational toolsen_US
dc.titleLiquid-Liquid Phase Separation Associated with Intrinsically Disordered Proteins: Experimental and Computational Tools
dc.typeArticle

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