Au-Pt nanoparticles based molecularly imprinted nanosensor for electrochemical detection of the lipopeptide antibiotic drug Daptomycin
| dc.contributor.author | Yarman, Aysu | |
| dc.contributor.author | Özçelikay, Göksu | |
| dc.contributor.author | Kurbanoğlu, Sevinç | |
| dc.contributor.author | Scheller, Frieder W. | |
| dc.contributor.author | Ozkan, Sibel A. | |
| dc.date.accessioned | 2024-04-25T13:04:25Z | |
| dc.date.available | 2024-04-25T13:04:25Z | |
| dc.date.issued | 2020 | |
| dc.department | TAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümü | en_US |
| dc.description.abstract | In this work, a novel electrochemical molecularly imprinted polymer (MIP) sensor for the detection of the lipopeptide antibiotic Daptomycin (DAP) is presented which integrates gold decorated platinum nanoparticles (Au-Pt NPs) into the nanocomposite film. The sensor was prepared by electropolymerization of o-phenylenediamine (o-PD) in the presence of DAP using cyclic voltammetry. Cyclic voltammetry and differential pulse voltammetry were applied to follow the changes in the MIP-layer related to rebinding and removal of the target DAP by using the redox marker [Fe(CN)6] 3?/4– . Under optimized operational conditions, the MIP/Au-Pt NPs/ GCE nanosensor exhibits a linear response in the range of 1-20 pM towards DAP. The limit of detection and limit of quantification were determined to be 0.161pM ± 0.012 and 0.489pM ± 0.012, respectively. The sensitivity towards the antibiotics Vancomycin and Erythromycin and the amino acids glycine and tryptophan was below 7 percent as compared with DAP. Moreover, the nanosensor was also successfully used for the detection of DAP in deproteinated human serum samples. | |
| dc.identifier.citation | Yarman, A., Özçelikay, G., Kurbanoğlu, S., Scheller, Frieder W., Ozkan, Sibel A. (2020). Au-Pt nanoparticles based molecularly imprinted nanosensor for electrochemical detection of the lipopeptide antibiotic drug Daptomycin, Sensors and Actuators B: Chemical, 320. | |
| dc.identifier.doi | 10.1016/j.snb.2020.128285 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12846/1153 | |
| dc.identifier.volume | 320 | en_US |
| dc.language.iso | en | |
| dc.relation.ispartof | Sensors and Actuators B: Chemical | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Molecularly imprinted polymer | en_US |
| dc.subject | Daptomycin | en_US |
| dc.subject | Platinum nanoparticles | en_US |
| dc.subject | Gold nanoparticles | en_US |
| dc.subject | Modified electrodes | en_US |
| dc.title | Au-Pt nanoparticles based molecularly imprinted nanosensor for electrochemical detection of the lipopeptide antibiotic drug Daptomycin | |
| dc.type | Article |
