Coherent organization in gene regulation a study on six networks

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dc.authorid0000-0002-5458-1053
dc.contributor.authorSözener, Neşe Aral
dc.contributor.authorKabakçıoğlu, Alkan
dc.date.accessioned2024-05-10T11:16:21Z
dc.date.available2024-05-10T11:16:21Z
dc.date.issued2016
dc.departmentTAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümüen_US
dc.description.abstractStructural and dynamical fingerprints of evolutionary optimization in biological networks are still unclear. Here we analyze the dynamics of genetic regulatory networks responsible for the regulation of cell cycle and cell differentiation in three organisms or cell types each, and show that they follow a version of Hebb's rule which we have termed coherence. More precisely, we find that simultaneously expressed genes with a common target are less likely to act antagonistically at the attractors of the regulatory dynamics. We then investigate the dependence of coherence on structural parameters, such as the mean number of inputs per node and the activatory/repressory interaction ratio, as well as on dynamically determined quantities, such as the basin size and the number of expressed genes.
dc.identifier.citationSözener, Neşe A., Kabakçıoğlu, A. (2016). Coherent organization in gene regulation a study on six networks. Physical Biology, 13 (2).
dc.identifier.doi10.1088/1478-3975/13/2/026006
dc.identifier.issue2en_US
dc.identifier.urihttps://iopscience.iop.org/article/10.1088/1478-3975/13/2/026006
dc.identifier.urihttps://hdl.handle.net/20.500.12846/1232
dc.identifier.volume13en_US
dc.language.isoen
dc.relation.ispartofPhysical Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleCoherent organization in gene regulation a study on six networks
dc.typeArticle

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