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Öğe Thermoresponsive intrinsically disordered protein polymers(Elsevier, 2024) Uversky, Vladimir N.; Tripathi, Timir; Coskuner-Weber, OrkidThermoresponsive intrinsically disordered protein polymers (TIDPPs) are a unique class of biopolymers that lack a fixed three-dimensional structure under physiological conditions and exhibit temperature-responsive behavior. These properties are primarily driven by their amino acid composition and sequence, which lead to changes in solubility and phase transitions at a critical temperature known as the lower critical solution temperature (LCST). TIDPPs transition from a soluble state below the LCST to an aggregated state above it, facilitating applications in drug delivery, tissue engineering, and smart biomaterials. The reversible phase behavior allows for precise control over drug release, targeted delivery, and scaffold properties, enhancing therapeutic efficacy and tissue regeneration. TIDPPs can be engineered to achieve specific LCST values, which make them highly versatile for various biomedical and industrial applications. Their biocompatibility and biodegradability further make them suitable for use in clinical settings, minimizing risks of adverse immune reactions. The field continues to explore the potential of TIDPPs with advanced bioengineering techniques for developing next-generation materials with tunable properties responsive to environmental stimuli. © 2025 Elsevier Inc. All rights reserved.
