Yazar "Sanli, Abdulkadir" seçeneğine göre listele

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    Biocompatibility of polymers
    (Elsevier, 2023) Sanli, Abdulkadir; Elibol, Cagatay; Aydınoğlu, Aysu
    Biocompatibility is defined as the ability of a material to perform with an appropriate host response in a specific application. Biocompatible polymers have gained significant importance during the past decades due to their capability to meet specific requirements for various applications such as tissue engineering, genetic disease treatment, and drug delivery. Biocompatibility testing of polymer-based medical devices is an essential requirement for regulatory approval. “EN ISO 10993 Biological evaluation of medical devices” includes several substandards prepared to manage biological risk and evaluate the biocompatibility of medical devices. The source of the polymeric biomaterial is determined by which biocompatibility test methods should be applied to the material itself. In this chapter, we present biocompatibility test methods and the main requirements of some common biocompatible polymers. In addition, we introduce some typical biomedical applications of these polymers after a detailed explanation of common natural and synthetic polymers. © 2023 Elsevier Ltd. All rights reserved.
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    Effects of Different Types of Surfactant Treatments on the Electromechanical Properties of Multiwalled Carbon Nanotubes Decorated Electrospun Nanofibers
    (E.U. Printing And Publishing House, 2024) Sanli, Abdulkadir; Cinfer, Sule Pinar; Yoruc, Afife Binnaz Hazar
    Carbon nanotubes (CNTs) have a strong tendency to form agglomeration due to van der Waals interactions, which hinders their practical utilization. Therefore, an effective and stable dispersion of CNTs in a surfactant based solvent is very important for the realization of CNTs based nanocomposites in various applications. In this paper, influence of different types of surfactant on the electromechanical properties of multiwalled carbon nanotubes (MWCNTs) decorated electrospun thermoplastic polyurethane (TPU) nanofibers were investigated by UV-VIS spectroscopy, zeta potential, FT-IR analysis, scanning electron microscopy (SEM) and uniaxial tensile strain sensing. Obtained results suggest that type of surfactant has not only effecting the dispersion level of CNTs but also has a significant influence on the electromechanical properties of CNTs decorated elecrospun CNTs/TPU nanofibers. The results of the present study provide new insights into the design and tailoring the electromechanical properties of CNTs decorated electrospun nanofibers.
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    Fabrication of electrospun nanofibrous clinoptilolite doped thermoplastic polyurethane scaffolds for skeletal muscle tissue engineering
    (Wiley, 2023) Yildirim, Meryem Akkurt; Sanli, Abdulkadir; Turkoglu, Nelisa; Denktas, Cenk
    The treatment of skeletal muscle, which lost its function with damage or trauma with autologous muscle tissue transfer, is a very problematic approach. Hence, it is critical to develop materials that are mimicking muscle tissue mechanical behaviors and allowing cell adhesion. Polyurethanes (PUs) are one of the most common polymers in tissue engineering applications and skeletal muscle regeneration due to their elasticity and mechanical flexibility. Clinoptilolite (CLN) is a hydrated alumina silica crystal based biocompatible material that numerous positive effects on animal and human health. Here, we report the synthesize of flexible membranes based on clinoptilolite (CLN) doped thermoplastic polyurethane (TPU) nanofiber network to be used in the field of skeletal muscle regeneration. We primarily evaluated their ability to mimic skeletal muscle by determining their mechanical properties and cell adhesion rates. We observe that cell adhesion and proliferation increased with the increase of CLN contribution. Young modulus (E-Y) values of pure TPU, 5 and 10 wt.% CLN-doped TPU fibers are 3.66, 2.37, and 1.85 MPa, respectively. Mechanical elongations at break of pure TPU, 5 and 10 wt.% CLN-doped TPU fibers after 37 degrees C treatment (7th day) are 193.41%, 113.30%, and 197.15%, respectively. With the addition of 5 wt.% CLN, the thermal stability slightly increased compared to the pure TPU and 10 wt.% CLN/TPU. In addition, cytotoxicity studies reveal that CLN/PU membranes are biocompatible, and finally cell adhesion increases proportionally to the increased CLN contribution. The obtained results indicate that the CLN/PU membranes can be used as a skeletal muscle scaffold.