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    Chemical profiling and antioxidant potential of propolis from Pervari, Siirt: discovery of tannic acid and key bioactive compounds
    (Informa UK Limited, 2025-01-24) Erkan Sırma; Mehmet Fidan; Mesut Gök; İbrahim Tegin; Mustafa Abdullah Yılmaz; Erdal Yabalak
    Propolis, a natural product with remarkable therapeutic potential, has gained attention for its antimicrobial, antioxidant, and anti-inflammatory properties. In this study, propolis samples from Sarıyaprak, Kovanağzı, and Çemikari in Pervari, Siirt province, were analysed comprehensively. The evaluation included wax composition, DPPH and FRAP assays, total phenolic and flavonoid content, and pollen analysis. Phytochemical compounds were identified using GC-MS and LC-MS/MS techniques. Among the regions, Çemikari samples exhibited the highest antioxidant activity and phenolic and flavonoid contents, with wax content averaging 60% across all locations. Key compounds identified via RSH-GC/MS included α-pinene, β-pinene, nonadecanal, and nonanal, while GC-MS revealed borneol, sedrenol, and benzyl alcohol. Significant phenolic compounds such as gallic acid, caffeic acid, and tannic acid (reported for the first time in Turkish propolis) were also detected. The high borneol concentration, with its strong anti-inflammatory properties, underscores the unique traits of these samples and their promising antioxidant potential for further research.
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    Evaluation of the Antioxidant, Antidiabetic and Anti-Alzheimer Effects of Capsella bursa-pastoris-Polyphenolic Profiling by LC-MS/MS
    (ACG Publications, 2024-12-26) İlhami Gülçin; Hasan Karageçili; Tuğba Polat; Mustafa Abdullah Yılmaz; Mehmet Fidan; Cengiz Karaismailoğlu
    Capsella bursa-pastoris species of the Capsella herb were examined in this study for sreening of antioxidant, antidiabetic and anti-Alzheimer effects. Traditionally, people consumed C. bursa-pastoris against famine and satisfy their hunger. C. bursa-pastoris species have been shown to have utility as food, medicine, and industrial materials after extensive investigation. The antioxidant properties of methanol and water extracts of C. bursa-pastoris species were assessed using; Fe3+-2,4,6-tris(2-pyridyl)-S-triazine (TPTZ), ferric (Fe3+), and cupric (Cu2+) iobs reducing assays, as well as 2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid radical (ABTS•+) and N,N-dimethyl-p-phenylenediamine (DMPD) radical scavenging activities. The antioxidant and reducing capacity of C. bursa-pastoris species aerial parts water and methanol extracts were compared with standard antioxidants. The phenolic and flavonoid contents in methanol and water extracts of C. bursa-pastoris species were measured 6.86 to 12.00 mg GAE/g and 61.67 to 145.0 mg QE/g, respectively. The inhibitions of effects of water and methanol extract of C. bursa-pastoris species against α-amylase, and acetylcholinesterase (AChE) enzymes were investigated. The IC50 values were found as 168.6 to 238.6 μg/mL against α-amylase and 19.0 to 20.9 μg/mL against AChE. The number of fenolik compounds in both extracts of C. bursa-pastoris species were recorded using LC-MS/MS. The major phenolic and flavonoid components detected in methanol extract of C. bursa-pastoris were quinic acid (22.629 mg/g), chlorogenic acid (3.211 mg/g), rutin (1.930 mg/g), hesperidin (0.893 mg/g), and isoquercitrin (0.783 mg/g). In a similar order, quinic acid (11.356 mg/g), cyranoside (9.463 mg/g), chlorogenic acid (6.072 mg/g), hesperidin (5.912 mg/g), and isoquercitrin (5.364 mg/g) were found as plentyfull pehenolic antioxidants in methanolic extract. The results clearly demonstrated that polyphenolic antioxidants-rich ingredients of the aerial parts of C. bursa-pastoris species are biological phenolic comounds have persuasive usage in the medication of diabetes and Alzheimer's diseases.