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Toplam kayıt 48, listelenen: 31-40
Epitope region identification challenges of intrinsically disordered proteins in neurodegenerative diseases: Secondary structure dependence of alpha-synuclein on simulation techniques and force field parameters
(Wiley, 2020)
Due to fast aggregation processes of many disordered proteins in neurodegenerative diseases, it is difficult to study their epitope regions at the monomeric and oligomeric levels. Computer simulations complement experiments ...
Polyketide synthase (PKS) reduces fusion of Legionella pneumophila-containing vacuoles with lysosomes and contributes to bacterial competitiveness during infection
(Elsevier Gmbh, Urban & Fischer Verlag, 2014)
L. pneumophila-containing vacuoles (LCVs) exclude endocytic and lysosomal markers in human macrophages and protozoa. We screened a L. pneumophila mini-Tn10 transposon library for mutants, which fail to inhibit the fusion ...
FKBPs in bacterial infections
(Elsevier Science Bv, 2015)
Background: FK506-binding proteins (FKBPs) contain a domain with peptidyl-prolyl-cis/trans-isomerase (PPlase) activity and bind the immunosuppressive drugs FK506 and rapamycin. FKBPs belong to the immunophilin family and ...
Calibration-free extraction of constitutive parameters of magnetically coupled anisotropic metamaterials using waveguide measurements
(Amer Inst Physics, 2017)
A calibration-free method for extraction of electromagnetic properties of magnetically coupled anisotropic biaxial metamaterial (MM) slabs from waveguide measurements is proposed. It relies on three measurement steps (thru, ...
Production of rare earth element oxide powders by solution combustion: a new approach for recycling of NdFeB magnets
(Royal Society of Chemistry, 2022)
NdFeB magnets are employed in various technological applications due to their outstanding magnetic properties, such as high maximum energy product, high remanence and high coercivity. Production of NdFeB has gathered more ...
Electrochemical MIP sensor for butyrylcholinesterase
(Mdpi, 2019)
Molecularly imprinted polymers (MIPs) mimic the binding sites of antibodies by substituting the amino acid-scaffold of proteins by synthetic polymers. In this work, the first MIP for the recognition of the diagnostically ...
Insights into the molecular mechanisms of Alzheimer's and Parkinson's diseases with molecular simulations: understanding the roles of artificial and pathological missense mutations in intrinsically disordered proteins related to pathology
(Mdpi, 2018)
Amyloid-beta and alpha-synuclein are intrinsically disordered proteins (IDPs), which are at the center of Alzheimer's and Parkinson's disease pathologies, respectively. These IDPs are extremely flexible and do not adopt ...
Classification of breast cancer histopathological images using DenseNet and transfer learning
(Hindawi Publishing Corporation, 2022)
Breast cancer is one of the most common invading cancers in women. Analyzing breast cancer is nontrivial and may lead to disagreements among experts. Although deep learning methods achieved an excellent performance in ...
Novel therapeutic strategies for Clostridium difficile infections
(Taylor & Francis Ltd, 2016)
Introduction: In recent years, Clostridium difficile has become the primary cause of antibiotic-associated diarrhea and pseudomembranous colitis, resulting in long and complicated hospital stays that represent a serious ...
Pleiotropic clostridioides difficile cyclophilin PpiB controls cysteine-tolerance, toxin production, the central metabolism and multiple stress responses
(Frontiers Media Sa, 2019)
The Gram-positive pathogen Clostridioides difficile is the main bacterial agent of nosocomial antibiotic associated diarrhea. Bacterial peptidyl-prolyl-cis/trans-isomerases (PPlases) are well established modulators of ...