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Toplam kayıt 81, listelenen: 21-30
3In-silico prediction of synergistic anti-cancer drug combinations using multi-omics data
(Nature Publishing Group, 2019)
Chemotherapy is a routine treatment approach for early-stage cancers, but the effectiveness of such treatments is often limited by drug resistance, toxicity, and tumor heterogeneity. Combination chemotherapy, in which two ...
Transition metal Ion interactions with disordered Amyloid-beta Peptides in the pathogenesis of Alzheimer's disease: insights from computational chemistry studies
(Amer Chemical Soc, 2019)
Monomers and oligomers of the amyloid-beta peptide aggregate to form the fibrils found in the brains of Alzheimer's disease patients. These monomers and oligomers are largely disordered and can interact with transition ...
Peptidylprolyl cis-trans isomerases of Legionella pneumophila: virulence, moonlighting and novel therapeutic targets
(Portland Press Ltd, 2014)
Legionella pneumophila, typically a parasite of free-living protozoa, can also replicate in human alveolar macrophages and lung epithelial cells causing Legionnaires' disease in humans, a severe atypical pneumonia. The ...
Challenges and limitations in the studies of glycoproteins: A computational chemist's perspective
(WILEY, 2021)
Experimenters face challenges and limitations while analyzing glycoproteins due to their high flexibility, stereochemistry, anisotropic effects, and hydration phenomena. Computational studies complement experiments and ...
Application of self-organizing artificial neural networks on simulated diffusion tensor images
(Hindawi Publishing Corporation, 2013)
Diffusion tensor magnetic resonance imaging (DTMRI) as a noninvasive modality providing in vivo anatomical information allows determination of fiber connections which leads to brain mapping. The success of DTMRI is very ...
Molecularly imprinted polymer based sensors for SARS-CoV-2: where are we now?
(MDPI-Multidisciplinary Digital Publishing Institute, 2022)
Since the first reported case of COVID-19 in 2019 in China and the official declaration from the World Health Organization in March 2021 as a pandemic, fast and accurate diagnosis of severe acute respiratory syndrome ...
BMP-2 and BMP-9 binding specificities with ALK-3 in aqueous solution with dynamics
(Elsevier Science Inc, 2017)
Signal ligands of the transforming growth factor-beta (TGF-beta) superfamily include the bone morphogenetic proteins (BMPs). BMPs bind to type I and type II serine-threonine kinase receptors and trigger the transphosphorylation ...
MIPs and aptamers for recognition of proteins in biomimetic sensing
(Mdpi, 2016)
Biomimetic binders and catalysts have been generated in order to substitute the biological pendants in separation techniques and bioanalysis. The two major approaches use either "evolution in the test tube" of nucleotides ...
Development of a larval zebrafish infection model for clostridioides difficile
(Journal Of Visualized Experiments, 2020)
Clostridioides difficile infection (CDI) is considered to be one of the most common healthcare-associated gastrointestinal infections in the United States. The innate immune response against C. difficile has been described, ...
Classification of brain electrophysiological changes in response to colour stimuli
(Springer, 2021)
In this study, the classification of ongoing brain activity occurring as a response to colour stimuli was managed and reported. Until now, the classification of the seen colour from brain electrical signals has not been ...