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dc.contributor.authorÇonka Yıldız, Tuba
dc.contributor.authorNurdan, Kıvanç
dc.contributor.authorBrill, Aaron B.
dc.contributor.authorWalenta, A. H.
dc.date.accessioned2021-01-08T21:51:28Z
dc.date.available2021-01-08T21:51:28Z
dc.date.issued2015
dc.identifier.issn1748-0221
dc.identifier.urihttp://doi.org/10.1088/1748-0221/10/07/C07018
dc.identifier.urihttps://hdl.handle.net/20.500.12846/287
dc.description16th International Workshop on Radiation Imaging Detectors, JUN 22-26, 2014, Trieste, ITALYen_US
dc.descriptionConka, Tuba/0000-0003-0671-3805en_US
dc.descriptionWOS:000362265600018en_US
dc.description.abstractThe proposed research focuses on the design criteria for a Compton Camera with high spatial resolution and sensitivity, operating at high gamma energies and its possible application for molecular imaging. This application is mainly on the detection and visualization of the pharmacokinetics of tumor targeting substances specific for particular cancer sites. Expected high resolution (< 0.5 mm) permits monitoring the pharmacokinetics of labeled gene constructs in vivo in small animals with a human tumor xenograft which is one of the first steps in evaluating the potential utility of a candidate gene. The additional benefit of high sensitivity detection will be improved cancer treatment strategies in patients based on the use of specific molecules binding to cancer sites for early detection of tumors and identifying metastasis, monitoring drug delivery and radionuclide therapy for optimum cell killing at the tumor site. This new technology can provide high resolution, high sensitivity imaging of a wide range of gamma energies and will significantly extend the range of radiotracers that can be investigated and used clinically. The small and compact construction of the proposed camera system allows flexible application which will be particularly useful for monitoring residual tumor around the resection site during surgery. It is also envisaged as able to test the performance of new drug/gene-based therapies in vitro and in vivo for tumor targeting efficacy using automatic large scale screening methods.en_US
dc.language.isoengen_US
dc.publisherIop Publishing Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCompton Imagingen_US
dc.subjectInstrumentation For Gamma-Electron Therapyen_US
dc.subjectDetector Modelling And Simulations I (Interaction Of Radiation With Matter, Interaction Of Photons With Matter, Interaction Of Hadrons With Matter, Etc)en_US
dc.subjectGamma Detectors (Scintillators, Czt, Hpg, Hgi Etc)en_US
dc.titleDesign criteria for a high energy Compton Camera and possible application to targeted cancer therapyen_US
dc.typeconferenceObjecten_US
dc.relation.journalJournal Of Instrumentationen_US
dc.identifier.volume10en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.contributor.departmentTAÜ, Mühendislik Fakültesi, Mekatronik Mühendisliği Bölümüen_US
dc.contributor.institutionauthorÇonka Yıldız, Tuba
dc.identifier.doi10.1088/1748-0221/10/07/C07018
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.wosWOS:000362265600018en_US


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