Erişim şekli için "info:eu-repo/semantics/openAccess" PubMed İndeksli Yayın Koleksiyonu listeleme
Toplam kayıt 25, listelenen: 1-20
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3In-silico prediction of synergistic anti-cancer drug combinations using multi-omics data
(Nature Publishing Group, 2019)Chemotherapy is a routine treatment approach for early-stage cancers, but the effectiveness of such treatments is often limited by drug resistance, toxicity, and tumor heterogeneity. Combination chemotherapy, in which two ... -
Classification of breast cancer histopathological images using DenseNet and transfer learning
(Hindawi Publishing Corporation, 2022)Breast cancer is one of the most common invading cancers in women. Analyzing breast cancer is nontrivial and may lead to disagreements among experts. Although deep learning methods achieved an excellent performance in ... -
The effect of preceramic soldering on fracture resistance of 4-unit zirconia fixed dental prostheses
(Wiley, 2022)Purpose Preceramic soldering of zirconia may deliver better fitting restorations. However, there is not sufficient evidence regarding the influence of preceramic soldering of zirconia restorations on mechanical strength. ... -
Electrochemical MIP sensor for butyrylcholinesterase
(Mdpi, 2019)Molecularly imprinted polymers (MIPs) mimic the binding sites of antibodies by substituting the amino acid-scaffold of proteins by synthetic polymers. In this work, the first MIP for the recognition of the diagnostically ... -
Electrosynthesized MIPs for transferrin: Plastibodies or nano-filters?
(Elsevier Advanced Technology, 2018)Molecularly imprinted polymer (MP) nanofilrns for transferrin (Trf) have been synthesized on gold surfaces by electro-polymerizing the functional monomer scopoletin in the presence of the protein target or around pre-adsorbed ... -
Harmony search optimisation of dispersed laminated composite plates
(Mdpi, 2020)One of the major goals in the process of designing structural components is to achieve the highest possible buckling load of the structural component while keeping the cost and weight at a minimum. This paper illustrates ... -
How an ACE2 mimicking epitope-MIP nanofilm recognizes template-related peptides and the receptor binding domain of SARS-CoV-2
(Royal Society of Chemistry, 2022)Here we aim to gain a mechanistic understanding of the formation of epitope-imprinted polymer nanofilms using a non-terminal peptide sequence, i.e. the peptide GFNCYFP (G485 to P491) of the SARS-CoV-2 receptor binding ... -
Insights into the molecular mechanisms of Alzheimer's and Parkinson's diseases with molecular simulations: understanding the roles of artificial and pathological missense mutations in intrinsically disordered proteins related to pathology
(Mdpi, 2018)Amyloid-beta and alpha-synuclein are intrinsically disordered proteins (IDPs), which are at the center of Alzheimer's and Parkinson's disease pathologies, respectively. These IDPs are extremely flexible and do not adopt ... -
Interpretable machine learning algorithms to predict the axial capacity of frp-reinforced concrete columns
(MDPI-Multidisciplinary Digital Publishing Institute, 2022)Fiber-reinforced polymer (FRP) rebars are increasingly being used as an alternative to steel rebars in reinforced concrete (RC) members due to their excellent corrosion resistance capability and enhanced mechanical properties. ... -
Ion-imprinted polymer-on-a-sensor for copper detection
(MDPI-Multidisciplinary Digital Publishing Institute, 2022)The accumulation of metal ions in the body is caused by human activities and industrial uses. Among these metal ions, copper is the third most abundant ion found in the human body and is indispensable for health because ... -
Matching algorithm for improving ride-sharing by incorporating route splits and social factors
(Public Library Science, 2020)Increasing traffic congestion and the advancements in technology have fostered the growth of alternative transportation modes such as dynamic ride-sharing. Smartphone technologies have enabled dynamic ride-sharing to thrive, ... -
Microbial peptidyl-prolyl cis/trans isomerases (ppIases): virulence factors and potential alternative drug targets
(Amer Soc Microbiology, 2014)Initially discovered in the context of immunomodulation, peptidyl-prolyl cis/trans isomerases (PPIases) were soon identified as enzymes catalyzing the rate-limiting protein folding step at peptidyl bonds preceding proline ... -
MIPs and aptamers for recognition of proteins in biomimetic sensing
(Mdpi, 2016)Biomimetic binders and catalysts have been generated in order to substitute the biological pendants in separation techniques and bioanalysis. The two major approaches use either "evolution in the test tube" of nucleotides ... -
Molecularly imprinted polymer based sensors for SARS-CoV-2: where are we now?
(MDPI-Multidisciplinary Digital Publishing Institute, 2022)Since the first reported case of COVID-19 in 2019 in China and the official declaration from the World Health Organization in March 2021 as a pandemic, fast and accurate diagnosis of severe acute respiratory syndrome ... -
New proposal for size and size-distribution evaluation of nanoparticles synthesized via ultrasonic spray pyrolysis using search algorithm based on image-processing technique
(Mdpi, 2020)Nanoparticle properties are correlated to their size, size distribution, and shape; it is essential to accurately measure these features in the field of nanoscience. In this study, silver nanoparticles (AgNPs) were synthesized ... -
Novel cycloheximide derivatives targeting the moonlighting protein Mip exhibit specific antimicrobial activity against Legionella pneumophila
(Frontiers Media Sa, 2015)Macrophage infectivity potentiator (Mip) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of ... -
Optimal dimensioning of retaining walls using explainable ensemble learning algorithms
(MDPI-Multidisciplinary Digital Publishing Institute, 2022)This paper develops predictive models for optimal dimensions that minimize the construction cost associated with reinforced concrete retaining walls. Random Forest, Extreme Gradient Boosting (XGBoost), Categorical Gradient ... -
Optimization and predictive modeling of reinforced concrete circular columns
(MDPI-Multidisciplinary Digital Publishing Institute, 2022)Metaheuristic optimization techniques are widely applied in the optimal design of structural members. This paper presents the application of the harmony search algorithm to the optimal dimensioning of reinforced concrete ... -
The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions
(Royal Soc, 2015)Macroautophagy is a highly conserved intracellular bulk degradation system of all eukaryotic cells. It is governed by a large number of autophagy proteins (ATGs) and is crucial for many cellular processes. Here, we describe ... -
Pleiotropic clostridioides difficile cyclophilin PpiB controls cysteine-tolerance, toxin production, the central metabolism and multiple stress responses
(Frontiers Media Sa, 2019)The Gram-positive pathogen Clostridioides difficile is the main bacterial agent of nosocomial antibiotic associated diarrhea. Bacterial peptidyl-prolyl-cis/trans-isomerases (PPlases) are well established modulators of ...