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Toplam kayıt 175, listelenen: 1-10
Microbial peptidyl-prolyl cis/trans isomerases (ppIases): virulence factors and potential alternative drug targets
(Amer Soc Microbiology, 2014)
Initially discovered in the context of immunomodulation, peptidyl-prolyl cis/trans isomerases (PPIases) were soon identified as enzymes catalyzing the rate-limiting protein folding step at peptidyl bonds preceding proline ...
MIPs and aptamers for recognition of proteins in biomimetic sensing
(Mdpi, 2016)
Biomimetic binders and catalysts have been generated in order to substitute the biological pendants in separation techniques and bioanalysis. The two major approaches use either "evolution in the test tube" of nucleotides ...
Pleiotropic clostridioides difficile cyclophilin PpiB controls cysteine-tolerance, toxin production, the central metabolism and multiple stress responses
(Frontiers Media Sa, 2019)
The Gram-positive pathogen Clostridioides difficile is the main bacterial agent of nosocomial antibiotic associated diarrhea. Bacterial peptidyl-prolyl-cis/trans-isomerases (PPlases) are well established modulators of ...
The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions
(Royal Soc, 2015)
Macroautophagy is a highly conserved intracellular bulk degradation system of all eukaryotic cells. It is governed by a large number of autophagy proteins (ATGs) and is crucial for many cellular processes. Here, we describe ...
Novel cycloheximide derivatives targeting the moonlighting protein Mip exhibit specific antimicrobial activity against Legionella pneumophila
(Frontiers Media Sa, 2015)
Macrophage infectivity potentiator (Mip) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of ...
The impact of the European Convention on Human Rights on the legal order of Turkey: achievements and problems
(2018)
The European Convention on Human Rights (ECHR/the Convention) is an effective legal supervision system that has made significant contributions to the improvement of human rights in the Member States of the Council of Europe. ...
Virtual extensometer analysis of martensite band nucleation, growth, and strain softening in pseudoelastic NiTi subjected to different load cases
(Mdpi, 2018)
Pseudoelastic NiTi shape memory alloys exhibit different stress-strain curves and modes of deformation in tension vs. compression. We have recently shown that under a combination of compression and shear, heterogeneous ...
Tuning the morphology of ZnO nanostructures with the ultrasonic spray pyrolysis process
(Mdpi, 2018)
Nanostructured zinc oxide (ZnO) particles were synthesized by the one step Ultrasonic Spray Pyrolysis (USP) process from nitrate salt solution (Zn(NO3)(2)center dot 6H(2)O). Various influential parameters, from Zn(NO3)(2)center ...
3In-silico prediction of synergistic anti-cancer drug combinations using multi-omics data
(Nature Publishing Group, 2019)
Chemotherapy is a routine treatment approach for early-stage cancers, but the effectiveness of such treatments is often limited by drug resistance, toxicity, and tumor heterogeneity. Combination chemotherapy, in which two ...
Enzymes as tools in MIP-Sensors
(Mdpi, 2017)
Molecularly imprinted polymers (MIPs) have the potential to complement antibodies in bioanalysis, are more stable under harsh conditions, and are potentially cheaper to produce. However, the affinity and especially the ...