Erişim şekli için "info:eu-repo/semantics/closedAccess" Moleküler Biyoteknoloji listeleme
Toplam kayıt 26, listelenen: 1-20
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Acute changes in electrophysiological brain dynamics in elite karate players
(Springer, 2020)Regular physical exercise has enhanced effects on the human anatomy and functionality. Recently, an effect of a single set of exercise is shown to have positive effects on mood and on cognitive functioning. The aim of this ... -
Alanine scanning effects on the biochemical and viophysical properties of intrinsically disordered proteins: a case study of the histidine to alanine mutations in amyloid-beta(42)
(Amer Chemical Soc, 2019)Alanine scanning is a tool in molecular biology that is commonly used to evaluate the contribution of a specific amino acid residue to the stability and function of a protein. Additionally, this tool is also used to ... -
Analysis of correlation between white matter changes and functional responses in thalamic stroke: a DTI & EEG study
(Springer, 2015)Diffusion tensor imaging (DTI) allows in vivo structural brain mapping and detection of microstructural disruption of white matter (WM). One of the commonly used parameters for grading the anisotropic diffusivity in WM is ... -
Bioreactors for tissue engineering
(Springer Cham, 2023)Bioreactors have been widely used in various fields of biological production for many years. Their ability to provide a tightly controlled environment during the process and to allow for monitoring and intervention to the ... -
BMP-2 and BMP-9 binding specificities with ALK-3 in aqueous solution with dynamics
(Elsevier Science Inc, 2017)Signal ligands of the transforming growth factor-beta (TGF-beta) superfamily include the bone morphogenetic proteins (BMPs). BMPs bind to type I and type II serine-threonine kinase receptors and trigger the transphosphorylation ... -
Challenges and limitations in the studies of glycoproteins: A computational chemist's perspective
(WILEY, 2021)Experimenters face challenges and limitations while analyzing glycoproteins due to their high flexibility, stereochemistry, anisotropic effects, and hydration phenomena. Computational studies complement experiments and ... -
Classification of brain electrophysiological changes in response to colour stimuli
(Springer, 2021)In this study, the classification of ongoing brain activity occurring as a response to colour stimuli was managed and reported. Until now, the classification of the seen colour from brain electrical signals has not been ... -
Current challenges and limitations in the studies of intrinsically disordered proteins in neurodegenerative diseases by computer simulations
(Bentham Science Publishers, 2020)Experiments face challenges in the analysis of intrinsically disordered proteins in solution due to fast conformational changes and enhanced aggregation propensity. Computational studies complement experiments, being widely ... -
Development of a larval zebrafish infection model for clostridioides difficile
(Journal Of Visualized Experiments, 2020)Clostridioides difficile infection (CDI) is considered to be one of the most common healthcare-associated gastrointestinal infections in the United States. The innate immune response against C. difficile has been described, ... -
Electrochemical MIP-sensors for drugs
(Bentham Science Publ Ltd, 2018)In order to replace bio-macromolecules by stable synthetic materials in separation techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional monomers are polymerized together with the ... -
Electrosynthesized molecularly imprinted polymer for laccase using the inactivated enzyme as the target
(Wiley-V C H Verlag Gmbh, 2018)The first molecularly imprinted polymer (MIP) for the recognition of the copper-enzyme laccase was successfully prepared by electropolymerizing scopoletin in the presence of alkaline-inactivated enzyme. Laccase-MIP and the ... -
Epitope region identification challenges of intrinsically disordered proteins in neurodegenerative diseases: Secondary structure dependence of alpha-synuclein on simulation techniques and force field parameters
(Wiley, 2020)Due to fast aggregation processes of many disordered proteins in neurodegenerative diseases, it is difficult to study their epitope regions at the monomeric and oligomeric levels. Computer simulations complement experiments ... -
FKBPs in bacterial infections
(Elsevier Science Bv, 2015)Background: FK506-binding proteins (FKBPs) contain a domain with peptidyl-prolyl-cis/trans-isomerase (PPlase) activity and bind the immunosuppressive drugs FK506 and rapamycin. FKBPs belong to the immunophilin family and ... -
Generating simulated DT-MRI dataset
(IGI Global, 2008)Diffusion tensor magnetic resonance imaging (DTMRI), also known as diffusion tensor imaging (DTI), needs post processing by adequate image analysis and visualization tools. White matter tractography using DTI is becoming ... -
Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases
(Elsevier Academic Press Inc, 2019)Amyloid-beta (A beta) and alpha-synuclein (alpha S) are two intrinsically disordered proteins (IDPs) at the centers of the pathogenesis of Alzheimer's and Parkinson's diseases, respectively. Different hypotheses have been ... -
Molecular LEGO by domain-imprinting of cytochrome P450 BM3
(Elsevier Science Bv, 2018)Hypothesis: Electrosynthesis of the MIP nano-film after binding of the separated domains or holocytochrome BM3 via an engineered anchor should result in domain-specific cavities in the polymer layer. Experiments: Both the ... -
NFI transcriptionally represses CDON and is required for SH-SY5Y cell survival
(Elsevier, 2022)Nuclear Factor One (NFI) family of transcription factors regulate proliferation and multiple aspects of differentiation, playing analogous roles in embryonic development and various types of cancer. While all NFI family ... -
Novel therapeutic strategies for Clostridium difficile infections
(Taylor & Francis Ltd, 2016)Introduction: In recent years, Clostridium difficile has become the primary cause of antibiotic-associated diarrhea and pseudomembranous colitis, resulting in long and complicated hospital stays that represent a serious ... -
Peptidylprolyl cis-trans isomerases of Legionella pneumophila: virulence, moonlighting and novel therapeutic targets
(Portland Press Ltd, 2014)Legionella pneumophila, typically a parasite of free-living protozoa, can also replicate in human alveolar macrophages and lung epithelial cells causing Legionnaires' disease in humans, a severe atypical pneumonia. The ... -
Polyketide synthase (PKS) reduces fusion of Legionella pneumophila-containing vacuoles with lysosomes and contributes to bacterial competitiveness during infection
(Elsevier Gmbh, Urban & Fischer Verlag, 2014)L. pneumophila-containing vacuoles (LCVs) exclude endocytic and lysosomal markers in human macrophages and protozoa. We screened a L. pneumophila mini-Tn10 transposon library for mutants, which fail to inhibit the fusion ...