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Polyketide synthase (PKS) reduces fusion of Legionella pneumophila-containing vacuoles with lysosomes and contributes to bacterial competitiveness during infection 

Shevchuk, Olga; Paegelow, Dennis; Rasch, Janine; Döhrmann, Simon; Günther, Gabriele; Hoppe, Julia; Steinert, Michael; Ünal, Can Murat; Bronietzki, Marc; Gutierrez, Maximiliano Gabriel (Elsevier Gmbh, Urban & Fischer Verlag, 2014)
L. pneumophila-containing vacuoles (LCVs) exclude endocytic and lysosomal markers in human macrophages and protozoa. We screened a L. pneumophila mini-Tn10 transposon library for mutants, which fail to inhibit the fusion ...
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Novel cycloheximide derivatives targeting the moonlighting protein Mip exhibit specific antimicrobial activity against Legionella pneumophila 

Rasch, Janine; Theuerkorn, Martin; Ünal, Can Murat; Heinsohn, Natascha; Tran, Stefan; Fischer, Gunter; Steinert, Michael (Frontiers Media Sa, 2015)
Macrophage infectivity potentiator (Mip) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of ...
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Peptidylprolyl cis-trans isomerases of Legionella pneumophila: virulence, moonlighting and novel therapeutic targets 

Rasch, Janine; Ünal, Can Murat; Steinert, Michael (Portland Press Ltd, 2014)
Legionella pneumophila, typically a parasite of free-living protozoa, can also replicate in human alveolar macrophages and lung epithelial cells causing Legionnaires' disease in humans, a severe atypical pneumonia. The ...



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Rasch, Janine (3)
Steinert, Michael (3)
Ünal, Can Murat (3)Bronietzki, Marc (1)Döhrmann, Simon (1)Fischer, Gunter (1)Gutierrez, Maximiliano Gabriel (1)Günther, Gabriele (1)Heinsohn, Natascha (1)Hoppe, Julia (1)... View MoreSubjectMoonlighting (2)Ppiase (2)Adamantane (1)Cycloheximide (1)Cyclophilin (1)Fitness (1)Fk506-Binding Protein (1)Inhibitor (1)Legionella (1)Legionella Pneumophila (1)... View MorePublication Typearticle (3)Languageeng (3)Publication CategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı (3)Access Typeinfo:eu-repo/semantics/closedAccess (2)info:eu-repo/semantics/openAccess (1)Date Issued2014 (2)2015 (1)Has File(s)Yes (3)

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