Yazar "TAÜ, Fen Fakültesi, Moleküler Biyoteknoloji Bölümü" için Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed listeleme
-
Transition metal Ion interactions with disordered Amyloid-beta Peptides in the pathogenesis of Alzheimer's disease: insights from computational chemistry studies
Strodel, Birgit; Weber, Orkide Coşkuner (Amer Chemical Soc, 2019)Monomers and oligomers of the amyloid-beta peptide aggregate to form the fibrils found in the brains of Alzheimer's disease patients. These monomers and oligomers are largely disordered and can interact with transition ... -
Tyrosine regulates beta-sheet structure formation in amyloid-beta(42): a new clustering algorithm for disordered proteins
Weber, Orkide Coşkuner; Uversky, Vladimir N. (Amer Chemical Soc, 2017)Our recent studies show that the single Tyr residue in the sequence of amyloid-beta(42) (A beta(42)) is reactive toward various ligands, including metals and adenosine trisphospate (see: Coskuner, O. J. Biol. Inorg. Chem. ... -
Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation
Scheithauer, Lina; Thiem, Stefanie; Schmelz, Stefan; Dellmann, Ansgar; Buessow, Konrad; Brouwer, Rene M. H. J.; Ünal, Can Murat; Blankenfeldt, Wulf; Steinert, Michael (Wiley, 2021)ProA is a secreted zinc metalloprotease of Legionella pneumophila causing lung damage in animal models of Legionnaires' disease. Here we demonstrate that ProA promotes infection of human lung tissue explants (HLTEs) and ...