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Toplam kayıt 48, listelenen: 21-30
Self-assembly of aromatic amino acids: a molecular dynamics study
(Royal Soc Chemistry, 2018)
The self assembly processes of aromatic amino acids, phenylalanine, tyrosine, and tryptophan have been simulated and were observed to form fibril-like aggregates linked to certain rare diseases and instances of biological ...
Development of a larval zebrafish infection model for clostridioides difficile
(Journal Of Visualized Experiments, 2020)
Clostridioides difficile infection (CDI) is considered to be one of the most common healthcare-associated gastrointestinal infections in the United States. The innate immune response against C. difficile has been described, ...
Microbial peptidyl-prolyl cis/trans isomerases (ppIases): virulence factors and potential alternative drug targets
(Amer Soc Microbiology, 2014)
Initially discovered in the context of immunomodulation, peptidyl-prolyl cis/trans isomerases (PPIases) were soon identified as enzymes catalyzing the rate-limiting protein folding step at peptidyl bonds preceding proline ...
Multifunctional alginate-based hydrogel with reversible crosslinking for controlled therapeutics delivery
(Elsevier, 2020)
Glycan-based alginate hydrogels have great potential in creating new vehicles with responsive behavior and tunable properties for biomedicine. However, precise control and tunability in properties present major barrier for ...
Green supplier evaluation with SWARA-TOPSIS integrated method to reduce ecological risk factors
(Springer, 2019)
One of the most important agendas of the world is the topic of global warming. In order to protect the ecological balance, all organizations turning towards using natural resources more effectively and not harming the ...
Alanine scanning effects on the biochemical and viophysical properties of intrinsically disordered proteins: a case study of the histidine to alanine mutations in amyloid-beta(42)
(Amer Chemical Soc, 2019)
Alanine scanning is a tool in molecular biology that is commonly used to evaluate the contribution of a specific amino acid residue to the stability and function of a protein. Additionally, this tool is also used to ...
NFI transcriptionally represses CDON and is required for SH-SY5Y cell survival
(Elsevier, 2022)
Nuclear Factor One (NFI) family of transcription factors regulate proliferation and multiple aspects of differentiation, playing analogous roles in embryonic development and various types of cancer. While all NFI family ...
Harmony search optimisation of dispersed laminated composite plates
(Mdpi, 2020)
One of the major goals in the process of designing structural components is to achieve the highest possible buckling load of the structural component while keeping the cost and weight at a minimum. This paper illustrates ...
Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases
(Elsevier Academic Press Inc, 2019)
Amyloid-beta (A beta) and alpha-synuclein (alpha S) are two intrinsically disordered proteins (IDPs) at the centers of the pathogenesis of Alzheimer's and Parkinson's diseases, respectively. Different hypotheses have been ...
Tyrosine regulates beta-sheet structure formation in amyloid-beta(42): a new clustering algorithm for disordered proteins
(Amer Chemical Soc, 2017)
Our recent studies show that the single Tyr residue in the sequence of amyloid-beta(42) (A beta(42)) is reactive toward various ligands, including metals and adenosine trisphospate (see: Coskuner, O. J. Biol. Inorg. Chem. ...