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Toplam kayıt 34, listelenen: 1-10
The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions
(Royal Soc, 2015)
Macroautophagy is a highly conserved intracellular bulk degradation system of all eukaryotic cells. It is governed by a large number of autophagy proteins (ATGs) and is crucial for many cellular processes. Here, we describe ...
How an ACE2 mimicking epitope-MIP nanofilm recognizes template-related peptides and the receptor binding domain of SARS-CoV-2
(Royal Society of Chemistry, 2022)
Here we aim to gain a mechanistic understanding of the formation of epitope-imprinted polymer nanofilms using a non-terminal peptide sequence, i.e. the peptide GFNCYFP (G485 to P491) of the SARS-CoV-2 receptor binding ...
Molecular LEGO by domain-imprinting of cytochrome P450 BM3
(Elsevier Science Bv, 2018)
Hypothesis: Electrosynthesis of the MIP nano-film after binding of the separated domains or holocytochrome BM3 via an engineered anchor should result in domain-specific cavities in the polymer layer. Experiments: Both the ...
Matching algorithm for improving ride-sharing by incorporating route splits and social factors
(Public Library Science, 2020)
Increasing traffic congestion and the advancements in technology have fostered the growth of alternative transportation modes such as dynamic ride-sharing. Smartphone technologies have enabled dynamic ride-sharing to thrive, ...
Single-shot full strain tensor determination with microbeam X-ray Laue diffraction and a two-imensional energy-dispersive detector
(Int Union Crystallography, 2017)
The full strain and stress tensor determination in a triaxially stressed single crystal using X-ray diffraction requires a series of lattice spacing measurements at different crystal orientations. This can be achieved using ...
Novel cycloheximide derivatives targeting the moonlighting protein Mip exhibit specific antimicrobial activity against Legionella pneumophila
(Frontiers Media Sa, 2015)
Macrophage infectivity potentiator (Mip) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of ...
The effect of preceramic soldering on fracture resistance of 4-unit zirconia fixed dental prostheses
(Wiley, 2022)
Purpose Preceramic soldering of zirconia may deliver better fitting restorations. However, there is not sufficient evidence regarding the influence of preceramic soldering of zirconia restorations on mechanical strength. ...
Optimal dimensioning of retaining walls using explainable ensemble learning algorithms
(MDPI-Multidisciplinary Digital Publishing Institute, 2022)
This paper develops predictive models for optimal dimensions that minimize the construction cost associated with reinforced concrete retaining walls. Random Forest, Extreme Gradient Boosting (XGBoost), Categorical Gradient ...
3In-silico prediction of synergistic anti-cancer drug combinations using multi-omics data
(Nature Publishing Group, 2019)
Chemotherapy is a routine treatment approach for early-stage cancers, but the effectiveness of such treatments is often limited by drug resistance, toxicity, and tumor heterogeneity. Combination chemotherapy, in which two ...
Peptidylprolyl cis-trans isomerases of Legionella pneumophila: virulence, moonlighting and novel therapeutic targets
(Portland Press Ltd, 2014)
Legionella pneumophila, typically a parasite of free-living protozoa, can also replicate in human alveolar macrophages and lung epithelial cells causing Legionnaires' disease in humans, a severe atypical pneumonia. The ...