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Microbial peptidyl-prolyl cis/trans isomerases (ppIases): virulence factors and potential alternative drug targets 

Ünal, Can Murat; Steinert, Michael (Amer Soc Microbiology, 2014)
Initially discovered in the context of immunomodulation, peptidyl-prolyl cis/trans isomerases (PPIases) were soon identified as enzymes catalyzing the rate-limiting protein folding step at peptidyl bonds preceding proline ...
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Pleiotropic clostridioides difficile cyclophilin PpiB controls cysteine-tolerance, toxin production, the central metabolism and multiple stress responses 

Ünal, Can Murat; Karagoz, Mustafa Safa; Berges, Mareike; Priebe, Christina; de Acuna, Jose Manuel Borrero; Wissing, Josef; Steinert, Michael (Frontiers Media Sa, 2019)
The Gram-positive pathogen Clostridioides difficile is the main bacterial agent of nosocomial antibiotic associated diarrhea. Bacterial peptidyl-prolyl-cis/trans-isomerases (PPlases) are well established modulators of ...
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Novel therapeutic strategies for Clostridium difficile infections 

Ünal, Can Murat; Steinert, Michael (Taylor & Francis Ltd, 2016)
Introduction: In recent years, Clostridium difficile has become the primary cause of antibiotic-associated diarrhea and pseudomembranous colitis, resulting in long and complicated hospital stays that represent a serious ...
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Polyketide synthase (PKS) reduces fusion of Legionella pneumophila-containing vacuoles with lysosomes and contributes to bacterial competitiveness during infection 

Shevchuk, Olga; Paegelow, Dennis; Rasch, Janine; Döhrmann, Simon; Günther, Gabriele; Hoppe, Julia; Steinert, Michael; Ünal, Can Murat; Bronietzki, Marc; Gutierrez, Maximiliano Gabriel (Elsevier Gmbh, Urban & Fischer Verlag, 2014)
L. pneumophila-containing vacuoles (LCVs) exclude endocytic and lysosomal markers in human macrophages and protozoa. We screened a L. pneumophila mini-Tn10 transposon library for mutants, which fail to inhibit the fusion ...
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The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions 

Xiong, Qiuhong; Ünal, Can Murat; Matthias, Jan; Steinert, Michael; Eichinger, Ludwig (Royal Soc, 2015)
Macroautophagy is a highly conserved intracellular bulk degradation system of all eukaryotic cells. It is governed by a large number of autophagy proteins (ATGs) and is crucial for many cellular processes. Here, we describe ...
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Novel cycloheximide derivatives targeting the moonlighting protein Mip exhibit specific antimicrobial activity against Legionella pneumophila 

Rasch, Janine; Theuerkorn, Martin; Ünal, Can Murat; Heinsohn, Natascha; Tran, Stefan; Fischer, Gunter; Steinert, Michael (Frontiers Media Sa, 2015)
Macrophage infectivity potentiator (Mip) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of ...
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Peptidylprolyl cis-trans isomerases of Legionella pneumophila: virulence, moonlighting and novel therapeutic targets 

Rasch, Janine; Ünal, Can Murat; Steinert, Michael (Portland Press Ltd, 2014)
Legionella pneumophila, typically a parasite of free-living protozoa, can also replicate in human alveolar macrophages and lung epithelial cells causing Legionnaires' disease in humans, a severe atypical pneumonia. The ...
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Development of a larval zebrafish infection model for clostridioides difficile 

Li, Junkai; Ünal, Can Murat; Namikawa, Kazuhiko; Steinert, Michael; Koester, Reinhard W. (Journal Of Visualized Experiments, 2020)
Clostridioides difficile infection (CDI) is considered to be one of the most common healthcare-associated gastrointestinal infections in the United States. The innate immune response against C. difficile has been described, ...
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FKBPs in bacterial infections 

Ünal, Can Murat; Steinert, Michael (Elsevier Science Bv, 2015)
Background: FK506-binding proteins (FKBPs) contain a domain with peptidyl-prolyl-cis/trans-isomerase (PPlase) activity and bind the immunosuppressive drugs FK506 and rapamycin. FKBPs belong to the immunophilin family and ...
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PrsA2 (CD630_35000) of clostridioides difficile Is an Active Parvulin-Type PPlase and a virulence modulator 

Ünal, Can Murat; Berges, Mareike; Smit, Nathiana; Schiene-Fischer, Cordelia; Priebe, Christina; Strowig, Till; Steinert, Michael (Frontiers Media Sa, 2018)
Clostridioides difficile is the main cause for nosocomial antibiotic associated diarrhea and has become a major burden for the health care systems of industrial countries. Its main virulence factors, the small GTPase ...
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AuthorSteinert, Michael (11)
Ünal, Can Murat (11)
Rasch, Janine (3)Berges, Mareike (2)Priebe, Christina (2)Blankenfeldt, Wulf (1)Bronietzki, Marc (1)Brouwer, Rene M. H. J. (1)Buessow, Konrad (1)de Acuna, Jose Manuel Borrero (1)... View MoreSubjectClostridium Difficile (2)Fk506-Binding Protein (2)Legionella Pneumophila (2)Moonlighting (2)Ppiase (2)Adamantane (1)Alternative Drug Targets (1)Anaerobe (1)Antibiotic Resistance (1)Autophagy (1)... View MoreDate Issued2014 (3)2015 (3)2016 (1)2018 (1)2019 (1)2020 (1)2021 (1)Has File(s)Yes (11)

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