Browsing by Author "Scheller, Frieder W."
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Electrochemical MIP sensor for butyrylcholinesterase
Özçelikay, Göksu; Kurbanoğlu, Sevinç; Zhang, Xiaorong; Söz, Çağla; Wollenberger, Ulla; Özkan, Sibel Ayşıl; Scheller, Frieder W. (Mdpi, 2019)Molecularly imprinted polymers (MIPs) mimic the binding sites of antibodies by substituting the amino acid-scaffold of proteins by synthetic polymers. In this work, the first MIP for the recognition of the diagnostically ... -
Electrochemical MIP-sensors for drugs
Yarman, Aysu; Kurbanoğlu, Sevinç; Jetzschmann, Katharina J.; Özkan, Sibel A.; Wollenberger, Ulla; Scheller, Frieder W. (Bentham Science Publ Ltd, 2018)In order to replace bio-macromolecules by stable synthetic materials in separation techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional monomers are polymerized together with the ... -
Electrochemical readout of molecularly imprinted polymers: potentials and challenges
Yarman, Aysu; Özçelikay, Göksu; Kurbanoğlu, Sevinç; Peng, Lei; Söz, Çağla; Özkan, Sibel Ayşıl; Wollenberger, Ulla; Scheller, Frieder W. (2020)Molecularly imprinted polymers (MIPs) are one of the most frequently studied alternative recognition elements in chromatography and sensorics. They are prepared by polymerizing the target analyte (socalled template) and ... -
Electrosynthesized MIPs for transferrin: Plastibodies or nano-filters?
Zhang, Xiaorong; Yarman, Aysu; Erdossy, Julia; Katz, Sagie; Zebger, Ingo; Jetzschmann, Katharina J.; Scheller, Frieder W. (Elsevier Advanced Technology, 2018)Molecularly imprinted polymer (MP) nanofilrns for transferrin (Trf) have been synthesized on gold surfaces by electro-polymerizing the functional monomer scopoletin in the presence of the protein target or around pre-adsorbed ... -
Enzymes as tools in MIP-Sensors
Yarman, Aysu; Jetzschmann, Katharina J.; Neumann, Bettina; Zhang, Xiaorong; Wollenberger, Ulla; Cordin, Aude; Scheller, Frieder W. (Mdpi, 2017)Molecularly imprinted polymers (MIPs) have the potential to complement antibodies in bioanalysis, are more stable under harsh conditions, and are potentially cheaper to produce. However, the affinity and especially the ... -
How an ACE2 mimicking epitope-MIP nanofilm recognizes template-related peptides and the receptor binding domain of SARS-CoV-2
Zhang, Xiaorong; Waffo, Armel T.; Yarman, Aysu; Kovacs, Norbert; Bognar, Zsofia; Wollenberger, Ulla; El-Sherbiny, Ibrahim M.; Hassan, Rabeay Y. A.; Bier, Frank F.; Gyurcsanyi, Robert E; Zebger, Ingo; Scheller, Frieder W. (Royal Society of Chemistry, 2022)Here we aim to gain a mechanistic understanding of the formation of epitope-imprinted polymer nanofilms using a non-terminal peptide sequence, i.e. the peptide GFNCYFP (G485 to P491) of the SARS-CoV-2 receptor binding ... -
MIPs and aptamers for recognition of proteins in biomimetic sensing
Menger, Marcus; Yarman, Aysu; Erdossy, Julia; Yıldız, Hüseyin Bekir; Gyurcsanyi, Robert E.; Scheller, Frieder W. (Mdpi, 2016)Biomimetic binders and catalysts have been generated in order to substitute the biological pendants in separation techniques and bioanalysis. The two major approaches use either "evolution in the test tube" of nucleotides ... -
Molecular LEGO by domain-imprinting of cytochrome P450 BM3
Jetzschmann, Katharina J.; Yarman, Aysu; Rustam, L.; Kielb, P.; Urlacher, V. B.; Fischer, A.; Scheller, Frieder W. (Elsevier Science Bv, 2018)Hypothesis: Electrosynthesis of the MIP nano-film after binding of the separated domains or holocytochrome BM3 via an engineered anchor should result in domain-specific cavities in the polymer layer. Experiments: Both the ...
